Pulse lineResearch With Heart Logo

Migraine and other headaches: associations with Rose angina and coronary heart disease.

TitleMigraine and other headaches: associations with Rose angina and coronary heart disease.
Publication TypeJournal Article
Year of Publication2004
AuthorsRose KM, Carson AP, Sanford CP, Stang PE, Brown CA, Folsom AR, Szklo M
JournalNeurology
Volume63
Issue12
Pagination2233-9
Date Published2004 Dec 28
ISSN1526-632X
KeywordsAdult, African Americans, Aged, Arteriosclerosis, Chest Pain, Cohort Studies, Comorbidity, Coronary Disease, Diabetes Mellitus, European Continental Ancestry Group, Female, Fibrinogen, Headache, Humans, Hypercholesterolemia, Hypertension, Income, Male, Middle Aged, Migraine with Aura, Migraine without Aura, Physical Exertion, Prevalence, Risk Factors, Sex Factors, Surveys and Questionnaires, United States, Vasoconstriction
Abstract

OBJECTIVE: To examine the association between a lifetime history of migraines and other headaches with and without aura and Rose angina and coronary heart disease (CHD).

METHODS: Participants were 12,409 African American and white men and women from the Atherosclerosis Risk in Communities Study, categorized by their lifetime history of headaches lasting > or =4 hours (migraine with aura, migraine without aura, other headaches with aura, other headaches without aura, no headaches). Gender-specific associations of headaches with Rose angina and CHD, adjusted for sociodemographic and cardiovascular disease risk factors, were evaluated using Poisson regression.

RESULTS: Participants with a history of migraines and other headaches were more likely to have a history of Rose angina than those without headaches. The associations were stronger for migraine and other headaches with aura (prevalence ratio [PR] = 3.0, 95% CI = 2.4, 3.7 and PR = 2.0, 95% CI = 1.5, 2.7 for women; PR = 2.2, 95% CI = 1.2, 3.9 and PR = 2.4, 95% CI = 1.4, 3.9 for men) than for migraine and other headaches without aura (PR = 1.5, 95% CI = 1.2, 1.9 and PR = 1.3, 95% CI = 1.1, 1.6 for women; PR = 1.9, 95% CI = 1.2, 2.9 and OR = 1.4, 95% CI = 1.0, 1.8 for men). In contrast, migraine and other headaches were not associated with CHD, regardless of the presence of aura.

CONCLUSIONS: The lack of association of migraines with coronary heart disease suggests that the association of migraine with Rose angina is not related to coronary artery disease. Future research assessing other common underlying pathologic mechanisms is warranted.

DOI10.1212/01.wnl.0000147289.50605.dc
Alternate JournalNeurology
PubMed ID15623679
Grant List5T32HL07055 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States