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Epidemiology of mitral annular calcification and its predictive value for coronary events in African Americans: the Jackson Cohort of the Atherosclerotic Risk in Communities Study.

TitleEpidemiology of mitral annular calcification and its predictive value for coronary events in African Americans: the Jackson Cohort of the Atherosclerotic Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2004
AuthorsFox E, Harkins D, Taylor H, McMullan M, Han H, Samdarshi T, Garrison R, Skelton T
JournalAm Heart J
Volume148
Issue6
Pagination979-84
Date Published2004 Dec
ISSN1097-6744
KeywordsAfrican Americans, Aged, Calcinosis, Cohort Studies, Coronary Artery Disease, Diabetes Complications, Female, Heart Valve Diseases, Humans, Hypertension, Kidney Diseases, Male, Middle Aged, Mitral Valve, Myocardial Infarction, Prevalence, Prognosis, Proportional Hazards Models, Risk Factors, Ultrasonography
Abstract

BACKGROUND: Despite the potential link between mitral annular calcification (MAC) and atherosclerosis, there is limited data regarding the prevalence of MAC in African Americans and its relationship with coronary heart disease (CHD)events in this high-risk population.

METHODS: The study population included 2409 African American participants of the Artherosclerotic Risk in Communities study (ARIC) undergoing echo examinations between 1993-1996. The primary outcome was incident CHD events [defined as fatal coronary event, hospitalized myocardial infarction or cardiac procedure]. MAC was considered a binary variable (yes/no). The Cox proportional hazard model was used for the analysis and the model was adjusted for gender, age, body mass index, hypertension, diabetes, smoking status, renal function (based on serum creatinine), high LDL and low HDL.

RESULTS: Of the 2409 in the study population, 1549 (64%) were women and the mean age was 59.2 +/- 5.8 years (range 49-75). MAC was positively associated with age and renal function. The overall prevalence of MAC was 4.6% for women and 5.6% for men. In participants aged >or= 70, the prevalence of MAC was 10% in women and 15.2% in men. During a median follow-up of 4.8 years, there were 237 total incident CHD events recorded. After adjustment, the hazard ratio for CHD events among the MAC subgroup was 2.32 (95% CI, 1.11-4.87).

CONCLUSIONS: In this relatively young population of middle-aged African Americans, the prevalence of MAC is low; however, the presence of MAC incurs a significant risk for coronary events.

DOI10.1016/j.ahj.2004.05.048
Alternate JournalAm Heart J
PubMed ID15632881
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States