|Title||The association of spatial T wave axis deviation with incident coronary events. The ARIC cohort.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Vaidean GD, Rautaharju PM, Prineas RJ, Whitsel EA, Chambless LE, Folsom AR, Rosamond WD, Zhang Z-M, Crow RS, Heiss G|
|Journal||BMC Cardiovasc Disord|
|Date Published||2005 Jan 11|
|Keywords||African Americans, Cohort Studies, Coronary Disease, Electrocardiography, Female, Humans, Hypertension, Incidence, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Whites|
BACKGROUND: Although current evidence suggests that the spatial T wave axis captures important information about ventricular repolarization abnormalities, there are only a few and discordant epidemiologic studies addressing the ability of the spatial T wave axis to predict coronary heart disease (CHD) occurrence.
METHODS: This prospective study analyzed data from 12,256 middle-aged African American and white men and women, from the Atherosclerosis Risk in Communities Study (ARIC). Following a standardized protocol, resting standard 12-lead, 10-second electrocardiograms were digitized and analyzed with the Marquette GE program. The median follow-up time was 12.1 years; incident coronary heart disease comprised fatal and non-fatal CHD events.
RESULTS: The incidence rate of CHD was 4.26, 4.18, 4.28 and 5.62 per 1000 person-years respectively, across the spatial T wave axis quartiles. Among women for every 10 degrees increase in the spatial T wave axis deviation, there was an estimated increase in the risk of CHD of 1.16 (95% CI 1.04-1.28). After adjustment for age, height, weight, smoking, hypertension, diabetes, QRS axis and minor T wave abnormalities, this hazard rate ratio for women fell to 1.03 (0.92-1.14). The corresponding crude and adjusted hazard ratios for men were 1.05 (95% CI 0.96-1.15) and 0.95 (0.86-1.04) respectively.
CONCLUSIONS: In conclusion, this prospective, population-based, bi-ethnic study of men and women free of coronary heart disease at baseline shows that spatial T wave axis deviation is not associated with incident coronary events during long-term follow up. It is doubtful that spatial T wave axis deviation would add benefit in the prediction of CHD events above and beyond the current traditional risk factors.
|Alternate Journal||BMC Cardiovasc Disord|
|PubMed Central ID||PMC546201|