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Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans.

TitleRelation of aortic valve sclerosis to risk of coronary heart disease in African-Americans.
Publication TypeJournal Article
Year of Publication2005
AuthorsTaylor HA, Clark BL, Garrison RJ, Andrew ME, Han H, Fox ER, Arnett DK, Samdarshi T, Jones DW
JournalAm J Cardiol
Volume95
Issue3
Pagination401-4
Date Published2005 Feb 01
ISSN0002-9149
KeywordsAfrican Americans, Aged, Aortic Valve, Chi-Square Distribution, Coronary Artery Disease, Coronary Disease, Echocardiography, Female, Humans, Incidence, Male, Middle Aged, Mississippi, Prevalence, Proportional Hazards Models, Risk Factors
Abstract

To assess the relation between aortic valve sclerosis (AVS) and subsequent occurrence of coronary heart disease (CHD) events, we analyzed echocardiographic data obtained from 2,279 middle-aged African-Americans enrolled in the Jackson Mississippi Atherosclerosis Risk in Communities study cohort who were free of known CHD at the time of the examination. Cox regression analyses demonstrated a hazard ratio of 3.8 for incident first myocardial infarction or fatal CHD after adjusted for multiple risk factors, including markers of inflammation. An amplification of CHD risk in the AVS subgroup with high levels of serum inflammatory markers (the highest quartile of fibrinogen and von Willebrand Factor levels) demonstrated greater than fivefold higher risk of CHD associated with AVS than risk in the lowest quartile.

DOI10.1016/j.amjcard.2004.09.043
Alternate JournalAm J Cardiol
PubMed ID15670554