Title | Left ventricular structure and systolic function in African Americans: the Atherosclerosis Risk in Communities (ARIC) study. |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Nkomo VT, Arnett DK, Benjamin EJ, Liebson PR, Hutchinson RG, Skelton TN |
Journal | Ethn Dis |
Volume | 14 |
Issue | 4 |
Pagination | 483-8 |
Date Published | 2004 Autumn |
ISSN | 1049-510X |
Keywords | Aged, Black or African American, Cross-Sectional Studies, Echocardiography, Female, Humans, Hypertrophy, Left Ventricular, Longitudinal Studies, Male, Middle Aged, Prevalence, Regression Analysis, Systole, United States, Ventricular Function, Left |
Abstract | OBJECTIVES: To estimate prevalence of left ventricular (LV) hypertrophy and its relation to systolic function in a population-based sample of African Americans. DESIGN: A baseline 2D guided M-mode echocardiogram was conducted as part of a longitudinal cohort study to assess prevalence and cross-sectional relationships between echocardiographic and clinical parameters. SETTING: Data were collected as part of the Atherosclerosis Risk in Communities study. PARTICIPANTS: Analysis is limited to 1543 African Americans, aged 51-70 years, without clinically apparent cardiovascular or echocardiographically determined valvular disease. MAIN OUTCOME MEASURES: LV hypertrophy prevalence was defined as LV mass/ height2.7 > or = 51 g/m2.7. LV systolic chamber function was assessed at the midwall using the ratio of observed midwall fractional shortening (MWS%) to the value predicted from circumferential end-systolic stress. RESULTS: The prevalence of LV hypertrophy was 33% in men, 38% in women. The prevalence of concentric hypertrophy (LV hypertrophy with relative wall thickness > or = 0.45) was greater than that of eccentric hypertrophy (men: 24% vs 9%; women: 27% vs 11% women). Observed/predicted (O/P) MWS% was strongly and inversely related to LV mass/ height2.7 (P<.001 and="" lv="" hypertrophy="" the="" o="" mws="" was="" inversely="" related="" to="" mass="" quartile:="" in="" first="" fourth="" quartile="" of="" for="" men="" women="" respectively.="" adjusting="" age="" adiposity="" diabetes="" blood="" pressure="" antihypertensive="" medication="" use="" smoking="" did="" not="" remove="" association="" between=""> CONCLUSIONS: LV hypertrophy was highly prevalent in this population-based middle-aged sample of African Americans and was associated with poorer LV systolic chamber function. |
Alternate Journal | Ethn Dis |
PubMed ID | 15724766 |
Grant List | N01 HC55015 / HC / NHLBI NIH HHS / United States N01 HC55016 / HC / NHLBI NIH HHS / United States N01 HC55018 / HC / NHLBI NIH HHS / United States N01 HC55019 / HC / NHLBI NIH HHS / United States N01 HC55020 / HC / NHLBI NIH HHS / United States N01 HC55021 / HC / NHLBI NIH HHS / United States N01 HC55022 / HC / NHLBI NIH HHS / United States |