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Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults.

TitleAssociations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults.
Publication TypeJournal Article
Year of Publication2005
AuthorsBeck JD, Eke P, Lin D, Madianos P, Couper D, Moss K, Elter J, Heiss G, Offenbacher S
JournalAtherosclerosis
Volume183
Issue2
Pagination342-8
Date Published2005 Dec
ISSN0021-9150
KeywordsAntibodies, Anti-Idiotypic, Atherosclerosis, Bacteria, Bacterial Infections, Carotid Arteries, Carotid Artery Diseases, Female, Humans, Immunoglobulin G, Incidence, Male, Middle Aged, Mouth, Periodontitis, Prospective Studies, Residence Characteristics, Risk Factors, Tunica Intima, Ultrasonography, United States
Abstract

AIMS: The aims of this study are to describe the relationships between IgG antibodies to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking.

METHODS AND RESULTS: Our study is based on a subset of participants in the Atherosclerosis Risk in Communities (ARIC) Study, who received a complete periodontal examination during visit 4 (1996-1998). The outcome was mean carotid IMT>/=1mm assessed by B-mode ultrasound. The exposures were serum IgG antibody levels against 17 periodontal organisms using a whole bacterial checkerboard immunoblotting technique. Evaluation of all 17 antibodies indicated that antibody to Campylobacter rectus resulted in the best-fitting model (OR=2.3, 95% CI=1.83-2.84) and individuals with both high C. rectus and Peptostreptococcus micros titers had almost twice the prevalence of IMT>/=1mm than those with only a high C. rectus antibody (8.3% versus 16.3%). Stratification by smoking indicated that all microbial models significant for smokers were also significant for never smokers except for Porphyromonas gingivalis (p=0.08).

CONCLUSIONS: This is the first study to report a relationship between IgG antibody reactive to oral organisms and subclinical atherosclerosis with significant relationships evident in both ever and never smokers.

DOI10.1016/j.atherosclerosis.2005.03.017
Alternate JournalAtherosclerosis
PubMed ID15893320
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
R01-DE11551 / DE / NIDCR NIH HHS / United States