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The effect of weight history on glucose and lipids: the Atherosclerosis Risk in Communities Study.

TitleThe effect of weight history on glucose and lipids: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2005
AuthorsTruesdale KP, Stevens J, Cai J
JournalAm J Epidemiol
Volume161
Issue12
Pagination1133-43
Date Published2005 Jun 15
ISSN0002-9262
KeywordsAlcohol Drinking, Arteriosclerosis, Blood Glucose, Body Mass Index, Body Weight, Causality, Comorbidity, Continental Population Groups, Female, Humans, Lipids, Male, Maryland, Middle Aged, Minnesota, Mississippi, North Carolina, Obesity, Reference Values, Risk Factors, Sex Distribution, Smoking, Socioeconomic Factors
Abstract

Few studies have examined the impact of weight history. Extant data from the Atherosclerosis Risk in Communities Study were used to compare risk factors for normal-weight (body mass index: 18.5-24.9 kg/m(2)) adults with a history of weight loss (n = 775) with those for persons with a history of weight maintenance (n = 5,164). In this 1987-1998 US study, the authors also compared risk factors for pre-obese (body mass index: 25.0-29.9 kg/m(2)) adults with a history of weight gain (n = 1,296) versus weight maintenance (n = 6,721). They used mixed-models regression to adjust for ethnicity, gender, age, education, field center, smoking, alcohol consumption, follow-up time, and follow-up body mass index. Compared with adults with a history of weight maintenance, adults with a 3-year history of weight loss had more favorable total and low density lipoprotein cholesterol levels and similar glucose, high density lipoprotein cholesterol, and triglyceride levels. In contrast, pre-obese adults with a 3-year history of weight gain had equivalent glucose and lipid levels at follow-up compared with adults with a history of weight maintenance. These findings suggest that, in addition to current weight, weight history may impact glucose and lipid levels.

DOI10.1093/aje/kwi151
Alternate JournalAm J Epidemiol
PubMed ID15937022
PubMed Central IDPMC3234677
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
F32 DK061831-02 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
F32 DK 61831-02 / DK / NIDDK NIH HHS / United States
R21 HL 075314-01 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
F32 DK061831 / DK / NIDDK NIH HHS / United States
R21 HL075314-01 / HL / NHLBI NIH HHS / United States
R21 HL075314 / HL / NHLBI NIH HHS / United States