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Cerebral MRI findings and cognitive functioning: the Atherosclerosis Risk in Communities study.

TitleCerebral MRI findings and cognitive functioning: the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2005
AuthorsMosley TH, Knopman DS, Catellier DJ, Bryan N, Hutchinson RG, Grothues CA, Folsom AR, Cooper LS, Burke GL, Liao D, Szklo M
JournalNeurology
Volume64
Issue12
Pagination2056-62
Date Published2005 Jun 28
ISSN1526-632X
KeywordsAged, Aged, 80 and over, Atherosclerosis, Atrophy, Causality, Cerebral Arteries, Cerebral Cortex, Cerebral Infarction, Cerebrovascular Disorders, Cognition Disorders, Cohort Studies, Comorbidity, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Neuropsychological Tests, Predictive Value of Tests, Prospective Studies, United States
Abstract

OBJECTIVE: To examine the association between prevalent cerebral abnormalities identified on MRI and cognitive functioning in a predominantly middle-aged, population-based study cohort.

METHODS: Cerebral MRI was performed on 1,538 individuals (aged 55 to 72) from the Atherosclerosis Risk in Communities (ARIC) cohort, with no history of stroke or TIA, at study sites in Forsyth County, NC, and Jackson, MS. White matter hyperintensities (WMHs), ventricular size, and sulcal size were graded by trained neuroradiologists on a semiquantitative, 10-point scale. Cognitive functioning was assessed using the Delayed Word Recall Test (DWRT), Digit Symbol Substitution Test (DSST), and Word Fluency Test (WFT).

RESULTS: High ventricular grade was independently associated with significantly lower scores on the DWRT and DSST and greater risk (odds ratio [OR] 2.32, 95% confidence interval [CI] 1.51 to 3.56) of impaired scores (i.e.,

CONCLUSION: Common changes in brain morphology are associated with diminished cognitive functioning in middle-aged and young-elderly individuals.

DOI10.1212/01.WNL.0000165985.97397.88
Alternate JournalNeurology
PubMed ID15985571
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55017 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States