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Asthma and incident cardiovascular disease: the Atherosclerosis Risk in Communities Study.

TitleAsthma and incident cardiovascular disease: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2005
AuthorsSchanen JG, Iribarren C, Shahar E, Punjabi NM, Rich SS, Sorlie PD, Folsom AR
JournalThorax
Volume60
Issue8
Pagination633-8
Date Published2005 Aug
ISSN0040-6376
KeywordsArteriosclerosis, Asthma, Coronary Artery Disease, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Stroke, Vital Capacity
Abstract

BACKGROUND: A possible association between asthma and cardiovascular disease has been described in several exploratory studies.

METHODS: The association of self-reported, doctor diagnosed asthma and incident cardiovascular disease was examined in a biracial cohort of 45-64 year old adults (N = 13501) followed over 14 years.

RESULTS: Compared with never having asthma, the multivariate adjusted hazard ratio (HR) of stroke (n = 438) was 1.50 (95% CI 1.04 to 2.15) for a baseline report of ever having asthma (prevalence 5.2%) and 1.55 (95% CI 0.95 to 2.52) for current asthma (prevalence 2.7%). The relative risk of stroke was 1.43 (95% CI 1.03 to 1.98) using a time dependent analysis incorporating follow up reports of asthma. Participants reporting wheeze attacks with shortness of breath also had greater risk for stroke (HR = 1.56, 95% CI 1.18 to 2.06) than participants without these symptoms. The multivariate adjusted relative risk of coronary heart disease (n = 1349) was 0.87 (95% CI 0.66 to 1.14) for ever having asthma, 0.69 (95% CI 0.46 to 1.05) for current asthma at baseline, and 0.88 (95% CI 0.69 to 1.11) using the time dependent analysis.

CONCLUSIONS: Asthma may be an independent risk factor for incident stroke but not coronary heart disease in middle aged adults. This finding warrants replication and may motivate a search for possible mechanisms that link asthma and stroke.

DOI10.1136/thx.2004.026484
Alternate JournalThorax
PubMed ID16061703
PubMed Central IDPMC1747501
Grant ListN01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States