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Metabolic syndrome and echocardiographic left ventricular mass in blacks: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleMetabolic syndrome and echocardiographic left ventricular mass in blacks: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2005
AuthorsBurchfiel CM, Skelton TN, Andrew ME, Garrison RJ, Arnett DK, Jones DW, Taylor HA
JournalCirculation
Volume112
Issue6
Pagination819-27
Date Published2005 Aug 09
ISSN1524-4539
KeywordsAfrican Continental Ancestry Group, Aged, Atherosclerosis, Blood Pressure, Echocardiography, Female, Heart Ventricles, Humans, Lipids, Male, Metabolic Syndrome, Middle Aged, Mississippi, Organ Size, Risk Factors, Ventricular Dysfunction, Left, Ventricular Function, Left
Abstract

BACKGROUND: The metabolic syndrome has been associated with cardiovascular disease, but few studies have examined its relationship with subclinical measures such as echocardiographic left ventricular (LV) mass. This relationship is likely to be of particular importance in blacks, in whom both the metabolic syndrome and LV hypertrophy are common.

METHODS AND RESULTS: Echocardiography, performed at 1 of 4 sites in the Atherosclerosis Risk in Communities (ARIC) Study, was used to assess LV dimensions in 1572 black women and men aged 49 to 75 years in 1993-1996. Participants were categorized by number of metabolic syndrome characteristics (hypertension, dyslipidemia [low HDL cholesterol or high triglycerides], and glucose intolerance). Age-adjusted mean LV mass indexed by height (g/m) increased in a stepwise gradient with increasing number of metabolic syndrome disorders (none, any 1, any 2, all 3) in both women and men (125.1, 143.9, 153.7, 169.3 and 130.5, 148.7, 160.8, 170.2, respectively; P

CONCLUSIONS: In this cross-sectional population-based study of black women and men, the degree of metabolic syndrome clustering was strongly related to LV mass and its wall thickness components. These associations are consistent with a possible influence of underlying factors such as insulin resistance or other vascular processes on myocardial thickening and not on chamber size.

DOI10.1161/CIRCULATIONAHA.104.518498
Alternate JournalCirculation
PubMed ID16061739
Grant ListN01-HC-95170 / HC / NHLBI NIH HHS / United States
N01-HC-95171 / HC / NHLBI NIH HHS / United States
N01-HC-95172 / HC / NHLBI NIH HHS / United States
N01-HC-955015 / HC / NHLBI NIH HHS / United States
N01-HC-955016 / HC / NHLBI NIH HHS / United States
N01-HC-955018 / HC / NHLBI NIH HHS / United States
N01-HC-955019 / HC / NHLBI NIH HHS / United States
N01-HC-955020 / HC / NHLBI NIH HHS / United States
N01-HC-955022 / HC / NHLBI NIH HHS / United States