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Apolipoprotein E genotype and incident ischemic stroke: the Atherosclerosis Risk in Communities Study.

TitleApolipoprotein E genotype and incident ischemic stroke: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2005
AuthorsSturgeon JD, Folsom AR, Bray MS, Boerwinkle E
Secondary AuthorsBallantyne CM
Corporate AuthorsAtherosclerosis Risk in Communities Study Investigators
JournalStroke
Volume36
Issue11
Pagination2484-6
Date Published2005 Nov
ISSN1524-4628
KeywordsApolipoproteins E, Atherosclerosis, Cohort Studies, Female, Genotype, Humans, Ischemia, Lipids, Male, Middle Aged, Risk, Risk Factors, Sex Factors, Stroke, Vascular Diseases
Abstract

BACKGROUND AND PURPOSE: A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARIC).

METHODS: The ARIC cohort involves 15 792 men and women, aged 45 to 64 years at baseline and sampled from 4 U.S. communities. Between 1987 and 2001, 498 incident ischemic strokes occurred.

RESULTS: After stratifying by race and sex and adjusting for other nonlipid risk factors, there was no significant relation between the apoE genotype and incident stroke, except in black women (hazard ratio for epsilon2 genotype relative to epsilon3/epsilon3=0.53; 95% CI, 0.28 to 0.99).

CONCLUSIONS: For the most part, in this middle-aged sample, apoE was not a risk factor for incident ischemic stroke.

DOI10.1161/01.STR.0000185687.28520.3f
Alternate JournalStroke
PubMed ID16210555
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
R01-HL073366 / HL / NHLBI NIH HHS / United States
T32-HL07779 / HL / NHLBI NIH HHS / United States