|Title||Socioeconomic differences in progression of carotid intima-media thickness in the Atherosclerosis Risk in Communities study.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Ranjit N, Diez-Roux AV, Chambless L, Jacobs DR, Nieto JF, Szklo M|
|Journal||Arterioscler Thromb Vasc Biol|
|Date Published||2006 Feb|
|Keywords||African Continental Ancestry Group, Carotid Arteries, Carotid Artery Diseases, Disease Progression, European Continental Ancestry Group, Female, Humans, Male, Middle Aged, Risk Factors, Social Class, Tunica Intima, Tunica Media|
OBJECTIVE: To examine the association of socioeconomic factors with progression of carotid intimal-medial thickness (IMT) in middle-aged adults. Cross-sectional associations of IMT with socioeconomic status (SES) have been demonstrated in middle-aged cohorts. It is unclear whether these factors are associated with progression of IMT.
METHODS AND RESULTS: We examined IMT progression over 9 years among a middle-aged cohort of 12,085 black and white subjects free of cardiovascular disease recruited from 4 US sites participating in the Atherosclerosis Risk in Communities (ARIC) study. Baseline IMT was inversely related to SES among whites and blacks. Repeated measures regression models of IMT progression showed moderate inverse relationships of IMT progression with income in whites so that the difference in 5-year IMT progression rates between the highest and lowest categories was -11.5 microm (CI, -17.4 to -5.6). In contrast, among blacks, this gradient is reversed, with an 11.1 microm (CI, -0.1 to 22.3) difference in 5-year progression between highest and lowest income category. Generally, similar patterns were observed for other socioeconomic indicators. Patterns were not accounted for by baseline cardiovascular risk factors.
CONCLUSIONS: SES is inversely related to IMT progression in middle-aged whites but positively related to IMT progression among middle-aged blacks. These differences do not appear to be attributable to selective attrition or higher IMT among blacks at baseline.
|Alternate Journal||Arterioscler Thromb Vasc Biol|
|Grant List||N01-HC-55015 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
P5-MD000206 / MD / NIMHD NIH HHS / United States
R01-HL-64142 / HL / NHLBI NIH HHS / United States