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Lower extremity arterial disease assessed by ankle-brachial index in a middle-aged population of African Americans and whites: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleLower extremity arterial disease assessed by ankle-brachial index in a middle-aged population of African Americans and whites: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2005
AuthorsZheng Z-jie, Rosamond WD, Chambless LE, Nieto JF, Barnes RW, Hutchinson RG, Tyroler HA, Heiss G
Corporate AuthorsARIC Investigators
JournalAm J Prev Med
Volume29
Issue5 Suppl 1
Pagination42-9
Date Published2005 Dec
ISSN0749-3797
KeywordsAfrican Americans, Ankle, Atherosclerosis, Brachial Artery, Cross-Sectional Studies, European Continental Ancestry Group, Female, Humans, Longitudinal Studies, Lower Extremity, Male, Middle Aged
Abstract

BACKGROUND: Lower extremity arterial disease (LEAD) is one of the most common manifestations of atherosclerosis. Its epidemiologic characteristics have not been well described, particularly in African Americans. Our purpose was to estimate the prevalence of LEAD and its associations with cardiovascular risk factors in a biracial population of men and women aged 45 to 64 years.

METHODS: We examined 15,173 African-American and white men and women who participated in the baseline examination (1987-1989) of the Atherosclerosis Risk in Communities (ARIC) Study. LEAD was defined by a resting ankle-brachial index (ABI), the ratio of ankle systolic blood pressure to brachial systolic pressure, of

RESULTS: The age-adjusted prevalence of ABI

CONCLUSIONS: The prevalence of LEAD appears to be higher in African Americans than whites. Elevations in traditional cardiovascular risk factors are associated with a higher prevalence of LEAD across race/ethnic and gender groups.

DOI10.1016/j.amepre.2005.07.019
Alternate JournalAm J Prev Med
PubMed ID16389125
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States