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Blood pressure usually considered normal is associated with an elevated risk of cardiovascular disease.

TitleBlood pressure usually considered normal is associated with an elevated risk of cardiovascular disease.
Publication TypeJournal Article
Year of Publication2006
AuthorsKshirsagar AV, Carpenter M, Bang H, Wyatt SB, Colindres RE
JournalAm J Med
Volume119
Issue2
Pagination133-41
Date Published2006 Feb
ISSN1555-7162
KeywordsBlood Pressure, Cardiovascular Diseases, Cohort Studies, Coronary Disease, Diabetes Complications, Female, Humans, Male, Middle Aged, Proportional Hazards Models, Reference Values, Risk Factors, Stroke
Abstract

PURPOSE: Research on the risk of cardiovascular disease among individuals with prehypertension (blood pressure 120/80 to 139/89 mm Hg) is incomplete. Additional information among individuals with a high risk of cardiovascular disease complications may help to focus current and future efforts.

SUBJECTS AND METHODS: We performed a prospective cohort analysis among 8960 middle-aged adults in the Atherosclerosis Risk in Communities (ARIC) study. The exposure variables were blood pressure levels: high normal blood pressure, systolic blood pressure 130-139 mm Hg or diastolic blood pressure 85-89 mm Hg; and normal blood pressure, systolic blood pressure 120-129 mm Hg or diastolic blood pressure 80-84 mm Hg. The outcome was incident cardiovascular disease defined as fatal/nonfatal coronary heart disease, cardiac procedure, silent myocardial infarction, or ischemic stroke. Subgroup analysis was performed among blacks, diabetics, individuals aged 55-64 years, individuals with renal insufficiency, and among individuals with varying levels of low-density lipoprotein (LDL) cholesterol and body mass index (BMI).

RESULTS: Compared with optimal blood pressure (systolic blood pressure 30 kg/m2: RR for high normal blood pressure was 3.56 (95% CI, 1.99-6.35); and among individuals with LDL >160 mg/dL, RR for high normal blood pressure was 1.85 (95% CI, 1.26-2.72).

CONCLUSIONS: Individuals with prehypertensive levels of blood pressure have an increased risk of developing cardiovascular disease relative to those with optimal levels. The association is pronounced among blacks, among individuals with diabetes mellitus, and among those with high BMI.

DOI10.1016/j.amjmed.2005.08.023
Alternate JournalAm J Med
PubMed ID16443415
Grant ListN01-HC- 95171 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-95170 / HC / NHLBI NIH HHS / United States