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Lipoprotein(a) and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study.

TitleLipoprotein(a) and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2006
AuthorsOhira T, Schreiner PJ, Morrisett JD, Chambless LE, Rosamond WD, Folsom AR
JournalStroke
Volume37
Issue6
Pagination1407-12
Date Published2006 Jun
ISSN1524-4628
KeywordsAfrican Continental Ancestry Group, Brain Ischemia, European Continental Ancestry Group, Female, Humans, Incidence, Lipoprotein(a), Male, Middle Aged, Osmolar Concentration, Sex Distribution, Stroke
Abstract

BACKGROUND AND PURPOSE: Numerous case-control and cross-sectional studies have reported higher median lipoprotein(a) [Lp(a)] levels among stroke patients than controls, but existing prospective studies have not consistently shown an association. We sought to examine the relationship between plasma Lp(a) levels and the incidence of ischemic stroke among blacks and whites.

METHODS: Between 1987 and 1989, 14,221 men and women (3647 blacks and 10,574 whites) aged 45 to 64 years and free of clinical cardiovascular disease, took part in the first examination of the Atherosclerosis Risk in Communities (ARIC) study cohort. Lp(a) and other risk factors for cardiovascular disease were measured at baseline.

RESULTS: During the 13.5-year follow-up, 496 ischemic strokes occurred. Participants with Lp(a) > or =300 microg/mL had a 79% higher age, sex, and race-adjusted rate ratio (RR) of ischemic stroke than did those with Lp(a) levels or =300 microg/mL were 1.84 (95% CI, 1.05 to 3.07) in black women, 1.72 (95% CI, 0.86 to 3.48) in black men, 2.42 (95% CI, 1.30 to 4.53) in white women, and 1.18 (95% CI, 0.47 to 2.90) in white men. There was no significant increment in the RRs for 100 to 199 microg/mL and 200 to 299 microg/mL groups.

CONCLUSIONS: A high Lp(a) concentration is associated with a higher incidence of ischemic stroke in blacks and white women, but not in white men.

DOI10.1161/01.STR.0000222666.21482.b6
Alternate JournalStroke
PubMed ID16675734
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States