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The prognostic value of the mitral diastolic filling velocity ratio for all-cause mortality and cardiovascular morbidity in African Americans: the Atherosclerotic Risks in Communities (ARIC) study.

TitleThe prognostic value of the mitral diastolic filling velocity ratio for all-cause mortality and cardiovascular morbidity in African Americans: the Atherosclerotic Risks in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2006
AuthorsFox ER, Han H, Taylor HA, Walls UC, Samdarshi T, Skelton TN, Pan J, Arnett D
JournalAm Heart J
Volume152
Issue4
Pagination749-55
Date Published2006 Oct
ISSN1097-6744
KeywordsAfrican Americans, Aged, Atherosclerosis, Blood Flow Velocity, Cardiovascular Diseases, Cohort Studies, Diastole, Female, Humans, Incidence, Male, Middle Aged, Mitral Valve, Mortality, Multivariate Analysis, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Risk Assessment
Abstract

BACKGROUND: Although recent data suggest that the mitral diastolic early-to-late (E/A) ratio may be prognostic in selected population-based cohorts, its predictive value for morbidity and mortality in African Americans has not yet been well studied.

METHODS: The study population consisted of African American participants from the Jackson cohort of the Atherosclerotic Risks in Community Study. Three subgroups of E/A ratios were defined: E/A 1.5, using the middle group as reference. Cox proportional hazard models were used to assess the association between the E/A ratio and both all-cause mortality and incident cardiovascular disease (CVD). The mean follow-up period was 6.8 +/- 1.3 years.

RESULTS: Of the 2211 participants in the study population (mean age 62 years, 65.1% women), 8.2% had an E/A ratio 1.5. An E/A >1.5 was independently associated with all-cause mortality (hazard ratio [HR] 2.18, 95% confidence interval [CI] 1.20-4.03) in the multivariable model. An E/A .05).

CONCLUSIONS: In a population-based cohort of middle-aged African Americans, an E/A >1.5 independently predicts all-cause mortality. An E/A >1.5 and an E/A

DOI10.1016/j.ahj.2006.04.014
Alternate JournalAm Heart J
PubMed ID16996852
Grant List5R01-NS 17950 / NS / NINDS NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States