|Title||Is early age-related macular degeneration related to carotid artery stiffness? The Atherosclerosis Risk in Communities Study.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Cheung N, Liao D, Islam FMAmirul, Klein R, Wang J J, Wong T Y|
|Journal||Br J Ophthalmol|
|Date Published||2007 Apr|
|Keywords||Aged, Atherosclerosis, Blood Pressure, Carotid Artery, Common, Cross-Sectional Studies, Elasticity, Female, Humans, Hypertension, Macular Degeneration, Male, Middle Aged, Pulsatile Flow, Risk Factors, Smoking, Ultrasonography, Vascular Resistance|
BACKGROUND/PURPOSE: Atherosclerosis and vascular stiffness have been implicated in the pathogenesis of age-related macular degeneration (AMD). The association of carotid artery stiffness, a measure of arterial elasticity reflecting early atherosclerosis, with early AMD, was examined in this study.
METHODS: A population-based, cross-sectional study of 9954 middle-aged people (age range 51-72 years). The presence of AMD signs was determined from fundus photographs according to the Wisconsin grading protocol. Carotid arterial stiffness was measured from high-resolution ultrasonic echo tracking of the left common carotid artery, and was defined as an adjusted arterial diameter change (AADCmu). A smaller AADC reflects greater carotid artery stiffness. The associations of pulse pressure and carotid artery intima-media thickness (IMT) with early AMD signs were also analysed.
RESULTS: In the study population, 454 (4.6%) had early AMD. The mean (SD) AADC was 403 (127) mu. After adjusting for age, sex, race/centre, education, cigarette smoking, fasting glucose, lipid profile and inflammatory markers, a smaller AADC was found to be not associated with early AMD (odds ratio 0.94; 95% confidence interval, 0.71 to 1.25) or its component lesions. Other measures of arterial stiffness (pulse pressure) and atherosclerosis (carotid IMT) were also not associated with early AMD.
CONCLUSIONS: Carotid artery stiffness was not associated with signs of early AMD in this middle-aged population. These data provide no evidence of a link between age-related elastoid changes and early atherosclerotic processes in the carotid arteries and early AMD.
|Alternate Journal||Br J Ophthalmol|
|PubMed Central ID||PMC1994729|
|Grant List||N01-HC-55022 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-35126 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-35125 / HC / NHLBI NIH HHS / United States