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Parity and risk of type 2 diabetes: the Atherosclerosis Risk in Communities Study.

TitleParity and risk of type 2 diabetes: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2006
AuthorsNicholson WK, Asao K, Brancati F, Coresh J, Pankow JS, Powe NR
JournalDiabetes Care
Volume29
Issue11
Pagination2349-54
Date Published2006 Nov
ISSN0149-5992
KeywordsAtherosclerosis, Diabetes Mellitus, Type 2, Female, Humans, Incidence, Middle Aged, Obesity, Parity, Predictive Value of Tests, Pregnancy, Proportional Hazards Models, Prospective Studies, Risk Factors
Abstract

OBJECTIVE: While high parity is hypothesized to be associated with insulin resistance and type 2 diabetes, few studies have examined this association in diverse racial samples or geographical areas. Our objectives were to estimate the magnitude of association between parity and diabetes and to determine if higher parity is predictive of future risk of diabetes.

RESEARCH DESIGN AND METHODS: This was a population-based, prospective cohort study of 7,024 Caucasian and African-American women from the Atherosclerosis Risk in Communities study, a prospective epidemiological study of men and women aged 45-64 years, with 9 years of follow-up. Incident diabetes was defined by the 1997 American Diabetes Association diagnostic criteria. Parity was defined as the number of live births (no live births [nulliparity], one to two live births, three to four live births, and five or more live births [grandmultiparity]). Parity and risk of diabetes was estimated for 754 incident cases of diabetes with Cox proportional hazard regression models, adjusting for sociodemographic, clinical, and lifestyle factors and inflammatory markers.

RESULTS: Incidence rates were highest among women with five or more live births (23/1,000 person-years [95% CI 20.3-26.7]) and lowest among women with one to two live births (11/1,000 person-years [9.6-12.5]). Adjustment indicated that much of the risk was due to sociodemographic factors and higher obesity, but after adjustment for all covariates, grandmultiparity (five or more) was still associated with a 27% increased risk for diabetes (hazard ratio 1.27 [95% CI 1.02-1.57]).

CONCLUSIONS: Grandmultiparity is predictive of future risk of diabetes after adjustment for confounders.

DOI10.2337/dc06-0825
Alternate JournalDiabetes Care
PubMed ID17065666
Grant ListN01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
K24 DK002643 / DK / NIDDK NIH HHS / United States
2K24-DK-O2643-06A1 / DK / NIDDK NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
1K23 DK-067944 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
K23 DK067944 / DK / NIDDK NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States