|Title||Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sample.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Patwardhan AA, Larson MG, Levy D, Benjamin EJ, Leip EP, Keyes MJ, Wang TJ, Gottlieb DJ, Vasan RS|
|Date Published||2006 Oct|
|Keywords||Atrial Fibrillation, Body Mass Index, Cohort Studies, Female, Humans, Hypertension, Male, Middle Aged, Myocardial Infarction, Natriuretic Peptides, Obesity, Polysomnography, Prevalence, Residence Characteristics, Severity of Illness Index, Sleep Apnea, Obstructive|
STUDY OBJECTIVES: We hypothesized that alterations in cardiac hemodynamics associated with obstructive sleep apnea-hypopnea (OSAH) would be reflected in higher natriuretic peptide levels. We examined the association of OSAH with natriuretic peptides in a community-based sample.
DESIGN: Cross-sectional, retrospective, observational study.
SETTING: Framingham Heart Study Offspring Cohort and Sleep Heart Health Study.
PARTICIPANTS: Community-based sample of 623 individuals.
MEASUREMENTS: Full-montage home polysomnography was used to determine apnea-hypopnea index (AHI) and percentage of time with an oxyhemoglobin saturation
RESULTS: No statistically significant relations between OSAH indices and BNP were observed in the multivariable model. Compared with an AHI 30 events per hour, respectively. For NT-ANP, no significant relations were seen with AHI in the multivariable model (relative levels of 0.98, 0.91, and 0.90). An inverse association was observed between NT-ANP and PctLt90 in age- and sex-adjusted models (relative levels of 0.93, 0.87, and 0.80), although this association became statistically nonsignificant after adjusting for body mass index.
CONCLUSION: Lack of association of natriuretic peptides with OSAH indices suggests that undiagnosed OSAH may not be associated with major alterations in left ventricular function, as reflected in morning natriuretic peptide levels.