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Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study.

TitleDiabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2006
AuthorsFoppa M, Duncan BB, Arnett DK, Benjamin EJ, Liebson PR, Manolio TA, Skelton TN
JournalCardiovasc Ultrasound
Volume4
Pagination43
Date Published2006 Nov 08
ISSN1476-7120
KeywordsAfrican Americans, Aged, Atherosclerosis, Comorbidity, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Prevalence, Risk Assessment, Risk Factors, Sex Factors, Ultrasonography, United States, Ventricular Dysfunction, Left
Abstract

BACKGROUND: Cardiovascular risk associated with diabetes may be partially attributed to left ventricular structural abnormalities. However, the relations between left ventricular structure and diabetes have not been extensively studied in African-Americans.

METHODS: We studied 514 male and 965 female African-Americans 51 to 70 years old, in whom echocardiographic left ventricular mass measurements were collected for the ARIC Study. In these, we investigated the independent association of diabetes with left ventricular structural abnormalities.

RESULTS: Diabetes, hypertension and obesity prevalences were 22%, 57% and 45%, respectively. Unindexed left ventricular mass was higher with diabetes in both men (238.3 +/- 79.4 g vs. 213.7 +/- 58.6 g; p

CONCLUSION: In African-Americans, diabetes is associated with left ventricular hypertrophy and, with different patterns of left ventricular structural abnormalities between genders. Attenuation seen in adjusted associations suggests that the higher frequency of structural abnormalities seen in diabetes may be due to factors other than hyperglycemia.

DOI10.1186/1476-7120-4-43
Alternate JournalCardiovasc Ultrasound
PubMed ID17092348
PubMed Central IDPMC1654185
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States