|Title||Multiple lipid scoring system for prediction of coronary heart disease risk: application to African Americans.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Everett CJ, Mainous AG, Koopman RJ, Diaz VA|
|Journal||J Natl Med Assoc|
|Date Published||2006 Nov|
|Keywords||African Americans, Apolipoproteins B, Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Coronary Disease, Health Status Indicators, Humans, Lipids, Middle Aged, Predictive Value of Tests, Risk Assessment|
BACKGROUND: Clinicians often obtain a panel of lipids but then only use low-density-lipoprotein (LDL) cholesterol to make clinical decisions. We previously described the multiple lipid measure, a strategy that integrates information about seven lipid measures. Our current inquiry uses the multiple lipid measure to create a scoring system and validates that system in a second cohort.
METHODS AND RESULTS: A scoring system that uses total cholesterol, high-density lipoprotein (HDL) cholesterol, LDL cholesterol and triglycerides was developed and tested. African-American participants of the Atherosclerosis Risk in Communities (ARIC) Study were used to validate the multiple lipid measure score. For nonsmokers, scores > or = 2 had a hazard ratio of 4.25 (95% CI 1.92-9.40) compared to reference scores of or = 160 mg/dl had a hazard ratio of 2.31 (95% CI 1.13-4.75). For current smokers, the best conventional lipid measure was the total cholesterol/HDL cholesterol ratio, which was similar in predictive ability to the multiple lipid measure score. However, the multiple lipid measure score predicted an additional 10% of the cohort at risk compared to the total cholesterol/HDL cholesterol ratio.
CONCLUSIONS: The use of the multiple lipid scoring system improves the assessment of incident coronary heart disease risk and may have utility for clinicians in integrating lipid values.
|Alternate Journal||J Natl Med Assoc|
|PubMed Central ID||PMC2569773|
|Grant List||2 D54 HP-00023 / / PHS HHS / United States|