Title | Multiple lipid scoring system for prediction of coronary heart disease risk: application to African Americans. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Everett CJ, Mainous AG, Koopman RJ, Diaz VA |
Journal | J Natl Med Assoc |
Volume | 98 |
Issue | 11 |
Pagination | 1740-5 |
Date Published | 2006 Nov |
ISSN | 0027-9684 |
Keywords | Apolipoproteins B, Black or African American, Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Coronary Disease, Health Status Indicators, Humans, Lipids, Middle Aged, Predictive Value of Tests, Risk Assessment |
Abstract | BACKGROUND: Clinicians often obtain a panel of lipids but then only use low-density-lipoprotein (LDL) cholesterol to make clinical decisions. We previously described the multiple lipid measure, a strategy that integrates information about seven lipid measures. Our current inquiry uses the multiple lipid measure to create a scoring system and validates that system in a second cohort. METHODS AND RESULTS: A scoring system that uses total cholesterol, high-density lipoprotein (HDL) cholesterol, LDL cholesterol and triglycerides was developed and tested. African-American participants of the Atherosclerosis Risk in Communities (ARIC) Study were used to validate the multiple lipid measure score. For nonsmokers, scores > or = 2 had a hazard ratio of 4.25 (95% CI 1.92-9.40) compared to reference scores of or = 160 mg/dl had a hazard ratio of 2.31 (95% CI 1.13-4.75). For current smokers, the best conventional lipid measure was the total cholesterol/HDL cholesterol ratio, which was similar in predictive ability to the multiple lipid measure score. However, the multiple lipid measure score predicted an additional 10% of the cohort at risk compared to the total cholesterol/HDL cholesterol ratio. CONCLUSIONS: The use of the multiple lipid scoring system improves the assessment of incident coronary heart disease risk and may have utility for clinicians in integrating lipid values. |
Alternate Journal | J Natl Med Assoc |
PubMed ID | 17128681 |
PubMed Central ID | PMC2569773 |
Grant List | 2 D54 HP-00023 / / PHS HHS / United States |