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Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults.

TitleAssociations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults.
Publication TypeJournal Article
Year of Publication2007
AuthorsNettleton JA, Steffen LM, Ballantyne CM, Boerwinkle E, Folsom AR
JournalAtherosclerosis
Volume194
Issue2
Paginatione131-40
Date Published2007 Oct
ISSN1879-1484
KeywordsAfrican Americans, Cholesterol Ester Transfer Proteins, Cholesterol, HDL, Cohort Studies, Dietary Fats, European Continental Ancestry Group, Feeding Behavior, Female, Genotype, Humans, Lipase, Lipoprotein Lipase, Male, Middle Aged, Nutrition Surveys, Polymorphism, Single Nucleotide, Sex Factors, United States
Abstract

Polymorphisms in genes involved in HDL-cholesterol (HDL-C) metabolism influence plasma HDL-C concentrations. We examined whether dietary fat intake modified relations between HDL-C and polymorphisms in hepatic lipase (LIPC-514C-->T), cholesteryl ester transfer protein (CETP TaqIB), and lipoprotein lipase (LPL S447X) genes. Diet (food frequency questionnaire), plasma lipids, and LIPC, CETP, and LPL genotypes were assessed in approximately 12,000 White and African American adults. In both races and all genotypes studied, minor allele homozygotes had highest HDL-C concentrations compared to the other genotypes (Por=33.2% of energy had approximately 3-4 mg/dL higher HDL-C concentrations than CC and CT genotypes. In contrast, when fat intake was

DOI10.1016/j.atherosclerosis.2006.11.025
Alternate JournalAtherosclerosis
PubMed ID17157861
PubMed Central IDPMC2248232
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
R01 HL073366 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
HL73366 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
T32 HL07779 / HL / NHLBI NIH HHS / United States