Pulse lineResearch With Heart Logo

Lung function and ischemic stroke incidence: the Atherosclerosis Risk in Communities study.

TitleLung function and ischemic stroke incidence: the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2006
AuthorsHozawa A, Billings JL, Shahar E, Ohira T, Rosamond WD, Folsom AR
JournalChest
Volume130
Issue6
Pagination1642-9
Date Published2006 Dec
ISSN0012-3692
KeywordsAfrican Continental Ancestry Group, Arteriosclerosis, Cerebral Infarction, Cohort Studies, Cross-Sectional Studies, Female, Forced Expiratory Volume, Humans, Incidence, Linear Models, Male, Middle Aged, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Risk Factors, Smoking, Statistics as Topic, Vital Capacity
Abstract

BACKGROUND: Few studies have examined the relation between lung function and ischemic stroke incidence; none have studied African Americans.

METHODS: We followed 13,842 middle-aged adults initially free of stroke and coronary heart disease and observed 472 incident ischemic strokes over 13 years. Quartiles of FEV(1) as a percentage of predicted value (FEV(1)PP) and FVC as a percentage of a predicted value (FVCPP) were used as the indicators of lung function.

RESULTS: In the age-, race-, gender-, and education-adjusted models, both lung function measures were significantly inversely related to ischemic stroke incidence (linear trend for FEV(1)PP, p

CONCLUSIONS: Among white subjects, participants with impaired lung function have a modestly higher risk of ischemic stroke even if they have never smoked nor had respiratory symptoms.

DOI10.1378/chest.130.6.1642
Alternate JournalChest
PubMed ID17166977
Grant ListN01 HC 55015 / HC / NHLBI NIH HHS / United States
N01 HC 55016 / HC / NHLBI NIH HHS / United States
N01 HC 55018 / HC / NHLBI NIH HHS / United States
N01 HC 55019 / HC / NHLBI NIH HHS / United States
N01 HC 55020 / HC / NHLBI NIH HHS / United States
N01 HC 55021 / HC / NHLBI NIH HHS / United States
N01 HC 55022 / HC / NHLBI NIH HHS / United States