Title | Antibodies to periodontal organisms are associated with decreased kidney function. The Dental Atherosclerosis Risk In Communities study. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Kshirsagar AV, Offenbacher S, Moss KL, Barros SP, Beck JD |
Journal | Blood Purif |
Volume | 25 |
Issue | 1 |
Pagination | 125-32 |
Date Published | 2007 |
ISSN | 0253-5068 |
Keywords | Aged, Antibodies, Bacterial, Atherosclerosis, DNA, Bacterial, Female, Glomerular Filtration Rate, Humans, Immunoglobulin G, Kidney Failure, Chronic, Male, Middle Aged, Odds Ratio, Periodontal Diseases, Prospective Studies, Risk Factors |
Abstract | BACKGROUND/AIMS: Increasing evidence suggests that clinical signs of periodontal disease are independently associated with renal impairment. However, no studies have examined the possible linkage of kidney disease with serum antibody to oral pathogens. METHODS: The periodontal disease status was assessed in an older community-dwelling population (Dental Atherosclerosis Risk in Communities) to include: clinical measurements; oral biofilm microbial composition by DNA checkerboard, and serum antibody immunoglobulin-gamma (IgG) titers to specific bacteria by immunocheckerboard. Baseline characteristics were used to compute estimated glomerular filtration rate defining eGFR RESULTS: High levels of serum IgG to selected periodontal pathogens including Porphyromonas gingivalis, Treponema denticola and Aggregobacter actinomycetemcomitans were associated with an increased odds for GFR CONCLUSIONS: Elevated IgG to periodontal pathogens is significantly associated with impaired kidney function, independent of traditional risk factors. Prospective studies are necessary to confirm these findings. |
DOI | 10.1159/000096411 |
Alternate Journal | Blood Purif |
PubMed ID | 17170550 |
Grant List | N01 HC 55015 / HC / NHLBI NIH HHS / United States N01 HC 55016 / HC / NHLBI NIH HHS / United States N01 HC 55018 / HC / NHLBI NIH HHS / United States N01 HC 55019 / HC / NHLBI NIH HHS / United States N01 HC 55020 / HC / NHLBI NIH HHS / United States N01 HC 55021 / HC / NHLBI NIH HHS / United States N01 HC 55022 / HC / NHLBI NIH HHS / United States RR 00046 / RR / NCRR NIH HHS / United States |