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Antibodies to periodontal organisms are associated with decreased kidney function. The Dental Atherosclerosis Risk In Communities study.

TitleAntibodies to periodontal organisms are associated with decreased kidney function. The Dental Atherosclerosis Risk In Communities study.
Publication TypeJournal Article
Year of Publication2007
AuthorsKshirsagar AV, Offenbacher S, Moss KL, Barros SP, Beck JD
JournalBlood Purif
Volume25
Issue1
Pagination125-32
Date Published2007
ISSN0253-5068
KeywordsAged, Antibodies, Bacterial, Atherosclerosis, DNA, Bacterial, Female, Glomerular Filtration Rate, Humans, Immunoglobulin G, Kidney Failure, Chronic, Male, Middle Aged, Odds Ratio, Periodontal Diseases, Prospective Studies, Risk Factors
Abstract

BACKGROUND/AIMS: Increasing evidence suggests that clinical signs of periodontal disease are independently associated with renal impairment. However, no studies have examined the possible linkage of kidney disease with serum antibody to oral pathogens.

METHODS: The periodontal disease status was assessed in an older community-dwelling population (Dental Atherosclerosis Risk in Communities) to include: clinical measurements; oral biofilm microbial composition by DNA checkerboard, and serum antibody immunoglobulin-gamma (IgG) titers to specific bacteria by immunocheckerboard. Baseline characteristics were used to compute estimated glomerular filtration rate defining eGFR

RESULTS: High levels of serum IgG to selected periodontal pathogens including Porphyromonas gingivalis, Treponema denticola and Aggregobacter actinomycetemcomitans were associated with an increased odds for GFR

CONCLUSIONS: Elevated IgG to periodontal pathogens is significantly associated with impaired kidney function, independent of traditional risk factors. Prospective studies are necessary to confirm these findings.

DOI10.1159/000096411
Alternate JournalBlood Purif
PubMed ID17170550
Grant ListN01 HC 55015 / HC / NHLBI NIH HHS / United States
N01 HC 55016 / HC / NHLBI NIH HHS / United States
N01 HC 55018 / HC / NHLBI NIH HHS / United States
N01 HC 55019 / HC / NHLBI NIH HHS / United States
N01 HC 55020 / HC / NHLBI NIH HHS / United States
N01 HC 55021 / HC / NHLBI NIH HHS / United States
N01 HC 55022 / HC / NHLBI NIH HHS / United States
RR 00046 / RR / NCRR NIH HHS / United States