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Gene-environment interaction and the GNB3 gene in the Atherosclerosis Risk in Communities study.

TitleGene-environment interaction and the GNB3 gene in the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2007
AuthorsGrove ML, Morrison A, Folsom AR, Boerwinkle E, Hoelscher DM, Bray MS
JournalInt J Obes (Lond)
Volume31
Issue6
Pagination919-26
Date Published2007 Jun
ISSN0307-0565
KeywordsAdult, African Americans, Aged, Atherosclerosis, Cohort Studies, Exercise, Female, Gene Frequency, Genotype, Heterotrimeric GTP-Binding Proteins, Humans, Hypertension, Male, Middle Aged, Obesity, Polymorphism, Genetic, Prevalence, Protein Subunits, Risk Factors, United States
Abstract

OBJECTIVE: The purpose of this study was to investigate the interaction between the G-protein beta-3 (GNB3) 825C>T polymorphism and physical activity in relation to prevalent obesity and hypertension.

RESEARCH METHODS AND PROCEDURES: The GNB3 825C>T genotype was measured in a sample of 14,716 African Americans (AAs) and whites from the Atherosclerosis Risk in Communities (ARIC) study, and logistic regression was used to test for genetic effects and gene-environment interactions.

RESULTS: The GNB3 825C>T variant was not independently associated with prevalent obesity or hypertension in either AA or whites. However, we observed a significant interaction (PT polymorphism, obesity status and physical activity in predicting hypertension in the AA subjects. AA homozygotes for the 825T allele who were both obese and had a low activity level were 2.7 times more likely to be hypertensive, compared to non-obese, active 825C homozygotes (OR=2.71, 95% CI=1.19-6.17, P

DISCUSSION: Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.

DOI10.1038/sj.ijo.0803545
Alternate JournalInt J Obes (Lond)
PubMed ID17299380
Grant ListHL073366 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
UR6/CCU617218 / / PHS HHS / United States