|Title||Gene-environment interaction and the GNB3 gene in the Atherosclerosis Risk in Communities study.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Grove ML, Morrison A, Folsom AR, Boerwinkle E, Hoelscher DM, Bray MS|
|Journal||Int J Obes (Lond)|
|Date Published||2007 Jun|
|Keywords||Adult, African Americans, Aged, Atherosclerosis, Cohort Studies, Exercise, Female, Gene Frequency, Genotype, Heterotrimeric GTP-Binding Proteins, Humans, Hypertension, Male, Middle Aged, Obesity, Polymorphism, Genetic, Prevalence, Protein Subunits, Risk Factors, United States|
OBJECTIVE: The purpose of this study was to investigate the interaction between the G-protein beta-3 (GNB3) 825C>T polymorphism and physical activity in relation to prevalent obesity and hypertension.
RESEARCH METHODS AND PROCEDURES: The GNB3 825C>T genotype was measured in a sample of 14,716 African Americans (AAs) and whites from the Atherosclerosis Risk in Communities (ARIC) study, and logistic regression was used to test for genetic effects and gene-environment interactions.
RESULTS: The GNB3 825C>T variant was not independently associated with prevalent obesity or hypertension in either AA or whites. However, we observed a significant interaction (PT polymorphism, obesity status and physical activity in predicting hypertension in the AA subjects. AA homozygotes for the 825T allele who were both obese and had a low activity level were 2.7 times more likely to be hypertensive, compared to non-obese, active 825C homozygotes (OR=2.71, 95% CI=1.19-6.17, P
DISCUSSION: Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.
|Alternate Journal||Int J Obes (Lond)|
|Grant List||HL073366 / HL / NHLBI NIH HHS / United States |
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
UR6/CCU617218 / / PHS HHS / United States