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Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study.

TitleReduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2007
AuthorsKöttgen A, Russell SD, Loehr LR, Crainiceanu CM, Rosamond WD, Chang PP, Chambless LE, Coresh J
JournalJ Am Soc Nephrol
Volume18
Issue4
Pagination1307-15
Date Published2007 Apr
ISSN1046-6673
KeywordsAtherosclerosis, Cohort Studies, Coronary Disease, Female, Glomerular Filtration Rate, Heart Failure, Humans, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk Factors, Survival Analysis
Abstract

Reduced kidney function is a risk factor for cardiovascular morbidity and mortality, and both heart failure (HF) and kidney failure incidences are increasing. This study therefore sought to determine the effect of decreased kidney function on HF incidence in a population-based study of middle-aged adults. From 1987 through 2002, 14,857 participants of the Atherosclerosis Risk in Communities (ARIC) study who were free of prevalent HF at baseline were followed for incident HF hospitalization or death (International Classification of Diseases, Ninth Revision/10th Revision 428/I50). Estimated GFR (eGFR) was calculated using the abbreviated Modification of Diet in Renal Disease (MDRD) Study equation, and kidney function was categorized as normal (eGFR > or =90 ml/min per 1.73 m(2); n = 7143), mildly reduced (eGFR 60 to 89 ml/min per 1.73 m(2); n = 7311), and moderately/severely reduced (eGFR or =90 ml/min per 1.73 m(2) (18 versus 6 per 1000 person-years). The overall adjusted relative hazard of developing HF was 1.94 (1.49 to 2.53) for individuals with eGFR

DOI10.1681/ASN.2006101159
Alternate JournalJ Am Soc Nephrol
PubMed ID17344421
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States