|Title||Gingival crevicular fluid interleukin-1beta, prostaglandin E2 and periodontal status in a community population.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Zhong Y, Slade GD, Beck JD, Offenbacher S|
|Journal||J Clin Periodontol|
|Date Published||2007 Apr|
|Keywords||Aged, Body Mass Index, Cross-Sectional Studies, Dinoprostone, Female, Gingival Crevicular Fluid, Humans, Interleukin-1beta, Least-Squares Analysis, Linear Models, Male, Maryland, Middle Aged, Minnesota, Mississippi, Molecular Epidemiology, North Carolina, Periodontal Diseases, Periodontal Index, Smoking|
AIM: Interleukin-1 beta (IL-1beta) and prostaglandin E(2) (PGE(2)) are key inflammatory mediators involved in periodontal disease. The purposes of this molecular cross-sectional epidemiological study were to investigate relationships in a community sample between mean concentrations of IL-1beta and PGE(2) in gingival crevicular fluid (GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory response and/or periodontal disease.
MATERIAL AND METHODS: The sample comprised 6277 community-dwelling adults aged 52-74 years enrolled in the Atherosclerosis Risk in Communities (ARIC) study. IL-1beta and PGE(2) concentrations were measured using enzyme-linked immunosorbent assay. Person-level summary variables were computed for maximum pocket depth (MaxPD), maximum clinical attachment level (MaxCAL) and presence/absence of bleeding on probing (BOP). Mean GCF IL-1beta and PGE(2) concentrations were dependent variables in multiple linear regression models with periodontal measures and covariates as explanatory variables.
RESULTS: Both GCF IL-1beta and PGE(2) were positively related to MaxPD and BOP in multiple regression models (por=30 kg/m(2).
CONCLUSION: Higher levels of GCF IL-1beta and PGE(2) were significantly associated with clinical signs of periodontal disease and independently related to patient-based anthropomorphic measures, behaviours and exposures in community-dwelling adults.
|Alternate Journal||J Clin Periodontol|
|Grant List||DE-11,551 / DE / NIDCR NIH HHS / United States |
N01-HC-55,015 / HC / NHLBI NIH HHS / United States
N01-HC-55,016 / HC / NHLBI NIH HHS / United States
N01-HC-55,018 / HC / NHLBI NIH HHS / United States
N01-HC-55,019 / HC / NHLBI NIH HHS / United States
N01-HC-55,020 / HC / NHLBI NIH HHS / United States
N01-HC-55,021 / HC / NHLBI NIH HHS / United States
N01-HC-55,022 / HC / NHLBI NIH HHS / United States
RR-00046 / RR / NCRR NIH HHS / United States