|Title||Traffic exposure and lung function in adults: the Atherosclerosis Risk in Communities study.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Kan H, Heiss G, Rose KM, Whitsel E, Lurmann F, London SJ|
|Date Published||2007 Oct|
|Keywords||Air Pollutants, Cohort Studies, Cross-Sectional Studies, Female, Forced Expiratory Volume, Humans, Lung Diseases, Male, Middle Aged, Risk Factors, Vehicle Emissions, Vital Capacity|
BACKGROUND: Traffic exposure is a major contributor to ambient air pollution for people living close to busy roads. The relationship between traffic exposure and lung function remains inconclusive in adults.
METHODS: A cross-sectional study was conducted to investigate the association between traffic exposure and lung function in the Atherosclerosis Risk in Communities (ARIC) study, a community based cohort of 15 792 middle aged men and women. Traffic density and distance to major roads were used as measures of traffic exposure.
RESULTS: After controlling for potential confounders including demographic factors, personal and neighbourhood level socioeconomic characteristics, cigarette smoking and background air pollution, higher traffic density was significantly associated with lower forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in women. Relative to the lowest quartile of traffic density, the adjusted differences across increasing quartiles were 5.1, -15.4 and -21.5 ml for FEV1 (p value of linear trend across the quartiles = 0.041) and 1.2, -23.4 and -34.8 ml for FVC (p trend = 0.010). Using distance from major roads as a simpler index of traffic related air pollution exposure, the FEV1 was -15.7 ml (95% CI -34.4 to 2.9) lower and the FVC was -24.2 ml (95% CI -46.2 to -2.3) lower for women living within 150 m compared with subjects living further away. There was no significant effect of traffic density or distance to major roads on lung function in men. The FEV1/FVC ratio was not significantly associated with traffic exposure in either men or women.
CONCLUSIONS: This is the largest published study of traffic exposure and pulmonary function in adults to date. These results add to growing evidence that chronic exposure to traffic related air pollution may adversely affect respiratory health.
|PubMed Central ID||PMC2094260|
|Grant List||N01 HC55022 / HC / NHLBI NIH HHS / United States |
N01 HC55020 / HC / NHLBI NIH HHS / United States
Z01 ES043012-09 / / Intramural NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01 HC55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01 HC55019 / HC / NHLBI NIH HHS / United States
N01 HC55016 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01 HC55021 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
Z01 ES043012 / / Intramural NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01 HC55018 / HC / NHLBI NIH HHS / United States