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Migraine and retinal microvascular abnormalities: the Atherosclerosis Risk in Communities Study.

TitleMigraine and retinal microvascular abnormalities: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2007
AuthorsRose KM, Wong TY, Carson AP, Couper DJ, Klein R, Sharrett AR
JournalNeurology
Volume68
Issue20
Pagination1694-700
Date Published2007 May 15
ISSN1526-632X
KeywordsAfrican Americans, Arterioles, Atherosclerosis, Cohort Studies, Cross-Sectional Studies, Diabetic Retinopathy, Female, Headache, Humans, Hypertension, Male, Microcirculation, Middle Aged, Migraine Disorders, Migraine with Aura, Migraine without Aura, Retinal Diseases, Risk Factors, United States, Venules, Whites
Abstract

OBJECTIVE: This study examined the association between vascular headaches and retinal microvascular disease.

METHODS: We investigated the cross-sectional association between headaches (migraine/other headaches with aura, migraine without aura, other headaches without aura, no headaches) and retinal microvascular signs (retinopathy, focal arteriolar narrowing, arteriovenous nicking; arteriolar and venular calibers) among middle-aged African American and white men and women from the third examination of the Atherosclerosis Risk in Communities Study (1993 through 1995).

RESULTS: After controlling for age, gender, race, study center, and cardiovascular risk factors, we determined that persons with headaches were more likely to have retinopathy than those without a history of headaches (odds ratio [OR] = 1.38, 95% CI = 0.96 to 1.99 for migraine/other headaches with aura; OR = 1.49, 95% CI = 1.05 to 2.12 for migraine without aura; and OR = 1.28, 95% CI = 0.99 to 1.65 for other headaches). Associations with migraine were stronger among the subset of participants without a history of diabetes or hypertension (OR = 1.79, 95% CI = 1.09 to 2.95 for migraine/other headaches with aura; and OR = 1.74, 95% CI = 1.11 to 2.71 for migraine without aura). Headaches were not associated with focal arteriolar narrowing or arteriovenous nicking. Persons with headaches tended to have smaller mean arteriolar and venular calibers; however, these associations did not tend to persist among those without hypertension or diabetes.

CONCLUSION: Middle-aged persons with migraine and other headaches were more likely to have retinopathy signs, supporting the hypothesis that neurovascular dysfunction may underlie vascular headaches.

DOI10.1212/01.wnl.0000261916.42871.05
Alternate JournalNeurology
PubMed ID17502551
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States