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Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study.

TitleApolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2007
AuthorsLiew G, Shankar A, Wang J J, Klein R, Bray MS, Couper DJ, A Sharrett R, Wong TY
JournalArch Ophthalmol
Volume125
Issue6
Pagination813-8
Date Published2007 Jun
ISSN0003-9950
KeywordsAfrican Continental Ancestry Group, Aged, Alleles, Apolipoprotein E2, Apolipoprotein E3, Apolipoprotein E4, Blood Pressure, Coronary Artery Disease, Cross-Sectional Studies, European Continental Ancestry Group, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Retinal Diseases, Retinal Vessels, Risk Factors, United States
Abstract

OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene polymorphisms and retinal microvascular signs.

METHODS: Population-based, cross-sectional study. Participants from the Atherosclerosis Risk in Communities Study (n=10,036; aged 49-73 years) had retinal photographs taken in 1 randomly selected eye. Photographs were graded for presence of retinal microvascular signs using a standardized protocol; a computer-assisted method was used to measure retinal vessel diameter. DNA from blood samples was analyzed for common APOE alleles.

RESULTS: After adjusting for age, sex, systolic blood pressure, total serum cholesterol, triglycerides, and other covariates, APOE epsilon 4 was associated with nondiabetic retinopathy in white (multivariate-adjusted odds ratio, 1.3; 95% confidence interval, 1.0-1.6) and black (multivariate-adjusted odds ratio, 1.4; 95% confidence interval, 1.0-2.1) individuals. Other retinal microvascular signs were not strongly associated with APOE polymorphisms. Neither retinal arteriolar nor venular diameter was associated with APOE polymorphisms in white or black individuals.

CONCLUSIONS: Apolipoprotein E epsilon 4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.

DOI10.1001/archopht.125.6.813
Alternate JournalArch Ophthalmol
PubMed ID17562993
Grant ListHL073366 / HL / NHLBI NIH HHS / United States
N01-HC-35125 / HC / NHLBI NIH HHS / United States
N01-HC-35126 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
UR6/CCU617218 / / PHS HHS / United States