|Title||Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Liew G, Shankar A, Wang J J, Klein R, Bray MS, Couper DJ, A Sharrett R, Wong TY|
|Date Published||2007 Jun|
|Keywords||African Continental Ancestry Group, Aged, Alleles, Apolipoprotein E2, Apolipoprotein E3, Apolipoprotein E4, Blood Pressure, Coronary Artery Disease, Cross-Sectional Studies, European Continental Ancestry Group, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Retinal Diseases, Retinal Vessels, Risk Factors, United States|
OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene polymorphisms and retinal microvascular signs.
METHODS: Population-based, cross-sectional study. Participants from the Atherosclerosis Risk in Communities Study (n=10,036; aged 49-73 years) had retinal photographs taken in 1 randomly selected eye. Photographs were graded for presence of retinal microvascular signs using a standardized protocol; a computer-assisted method was used to measure retinal vessel diameter. DNA from blood samples was analyzed for common APOE alleles.
RESULTS: After adjusting for age, sex, systolic blood pressure, total serum cholesterol, triglycerides, and other covariates, APOE epsilon 4 was associated with nondiabetic retinopathy in white (multivariate-adjusted odds ratio, 1.3; 95% confidence interval, 1.0-1.6) and black (multivariate-adjusted odds ratio, 1.4; 95% confidence interval, 1.0-2.1) individuals. Other retinal microvascular signs were not strongly associated with APOE polymorphisms. Neither retinal arteriolar nor venular diameter was associated with APOE polymorphisms in white or black individuals.
CONCLUSIONS: Apolipoprotein E epsilon 4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.
|Alternate Journal||Arch Ophthalmol|
|Grant List||HL073366 / HL / NHLBI NIH HHS / United States |
N01-HC-35125 / HC / NHLBI NIH HHS / United States
N01-HC-35126 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
UR6/CCU617218 / / PHS HHS / United States