|Title||Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Hart Sailors ML, Folsom AR, Ballantyne CM, Hoelscher DM, Jackson AS, Linda Kao WH, Pankow JS, Bray MS|
|Journal||Diabetes Obes Metab|
|Date Published||2007 Jul|
|Keywords||Atherosclerosis, Body Mass Index, Body Size, Caspase 10, DNA Primers, Female, Genetic Variation, Genotype, Humans, Leptin, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Racial Groups, Risk Factors, Sex Characteristics|
AIM: To investigate the effects of variation in the leptin [LEP (19A>G)] and melanocortin-4 receptor [MC4R (V103I)] genes on obesity-related traits in 13 405 African-American (AA) and white participants from the Atherosclerosis Risk in Communities (ARIC) Study.
METHODS: We tested the association between the single-locus and multilocus genotypes and obesity-related measures [body mass index (BMI), body weight (BW), waist-hip ratio, waist circumference and leptin levels], adjusted for age, physical activity level, smoking status, diabetic status, prevalence of coronary heart disease, hypertension, stroke or transient ischaemic attack.
RESULTS: AA and white female carriers of the MC4R I103 allele exhibited significantly lower BW than non-carriers of this allele (p
CONCLUSION: These results suggest that variation within the LEP and MC4R genes is associated with reduced risk for obesity in females.
|Alternate Journal||Diabetes Obes Metab|
|Grant List||HL073366 / HL / NHLBI NIH HHS / United States |
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
UR6/CCU617218 / / PHS HHS / United States