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Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study.

TitleGenetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2007
AuthorsHart Sailors ML, Folsom AR, Ballantyne CM, Hoelscher DM, Jackson AS, Linda Kao WH, Pankow JS, Bray MS
JournalDiabetes Obes Metab
Volume9
Issue4
Pagination548-57
Date Published2007 Jul
ISSN1462-8902
KeywordsAtherosclerosis, Body Mass Index, Body Size, Caspase 10, Continental Population Groups, DNA Primers, Female, Genetic Variation, Genotype, Humans, Leptin, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Risk Factors, Sex Characteristics
Abstract

AIM: To investigate the effects of variation in the leptin [LEP (19A>G)] and melanocortin-4 receptor [MC4R (V103I)] genes on obesity-related traits in 13 405 African-American (AA) and white participants from the Atherosclerosis Risk in Communities (ARIC) Study.

METHODS: We tested the association between the single-locus and multilocus genotypes and obesity-related measures [body mass index (BMI), body weight (BW), waist-hip ratio, waist circumference and leptin levels], adjusted for age, physical activity level, smoking status, diabetic status, prevalence of coronary heart disease, hypertension, stroke or transient ischaemic attack.

RESULTS: AA and white female carriers of the MC4R I103 allele exhibited significantly lower BW than non-carriers of this allele (p

CONCLUSION: These results suggest that variation within the LEP and MC4R genes is associated with reduced risk for obesity in females.

DOI10.1111/j.1463-1326.2006.00637.x
Alternate JournalDiabetes Obes Metab
PubMed ID17587397
Grant ListHL073366 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
UR6/CCU617218 / / PHS HHS / United States