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n-3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study.

Titlen-3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2008
AuthorsBeydoun MA, Kaufman JS, Sloane PD, Heiss G, Ibrahim J
JournalPublic Health Nutr
Volume11
Issue1
Pagination17-29
Date Published2008 Jan
ISSN1368-9800
KeywordsAged, Atherosclerosis, Cognition Disorders, Cohort Studies, Fatty Acids, Omega-3, Female, Humans, Hypertension, Logistic Models, Male, Maryland, Middle Aged, Minnesota, Mississippi, Multivariate Analysis, North Carolina, Nutrition Assessment, Prospective Studies, Risk Factors, United States
Abstract

OBJECTIVE: Recent research indicates that n-3 fatty acids can inhibit cognitive decline, perhaps differentially by hypertensive status.

DESIGN: We tested these hypotheses in a prospective cohort study (the Atherosclerosis Risk in Communities). Dietary assessment using a food-frequency questionnaire and plasma fatty acid exposure by gas chromatography were completed in 1987-1989 (visit 1), while cognitive assessment with three screening tools--the Delayed Word Recall Test, the Digit Symbol Substitution Test of the Wechsler Adult Intelligence Scale-Revised and the Word Fluency Test (WFT)--was completed in 1990-1992 (visit 2) and 1996-1998 (visit 4). Regression calibration and simulation extrapolation were used to control for measurement error in dietary exposures.

SETTING: Four US communities--Forsyth County (North Carolina), Jackson (Mississippi), suburbs of Minneapolis (Minnesota) and Washington County (Maryland).

SUBJECTS: Men and women aged 50-65 years at visit 1 with complete dietary data (n = 7814); white men and women in same age group in the Minnesota field centre with complete plasma fatty acid data (n = 2251).

RESULTS: Findings indicated that an increase of one standard deviation in dietary long-chain n-3 fatty acids (% of energy intake) and balancing long-chain n-3/n-6 decreased the risk of 6-year cognitive decline in verbal fluency with an odds ratio (95% confidence interval) of 0.79 (0.66-0.95) and 0.81 (0.68-0.96), respectively, among hypertensives. An interaction with hypertensive status was found for dietary long-chain n-3 fatty acids (g day-1) and WFT decline (likelihood ratio test, P = 0.06). This exposure in plasma cholesteryl esters was also protective against WFT decline, particularly among hypertensives (OR = 0.51, P

CONCLUSION: One implication from our study is that diets rich in fatty acids of marine origin should be considered for middle-aged hypertensive subjects. To this end, randomised clinical trials are needed.

DOI10.1017/S1368980007000080
Alternate JournalPublic Health Nutr
PubMed ID17625029
PubMed Central IDPMC4863651
Grant ListN01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC 55019 / HC / NHLBI NIH HHS / United States
Z99 AG999999 / / Intramural NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01 HC 55022 / HC / NHLBI NIH HHS / United States
N01 HC 55021 / HC / NHLBI NIH HHS / United States
N01 HC 55016 / HC / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
N01 HC 55018 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55020 / HL / NHLBI NIH HHS / United States
N01 HC 55015 / HC / NHLBI NIH HHS / United States
N01 HC 55020 / HC / NHLBI NIH HHS / United States