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A review of population-based retinal studies of the microvascular contribution to cerebrovascular diseases.

TitleA review of population-based retinal studies of the microvascular contribution to cerebrovascular diseases.
Publication TypeJournal Article
Year of Publication2007
AuthorsA Sharrett R
JournalOphthalmic Epidemiol
Volume14
Issue4
Pagination238-42
Date Published2007 Jul-Aug
ISSN0928-6586
KeywordsCerebrovascular Disorders, Humans, Magnetic Resonance Imaging, Retinal Diseases, Retinal Vessels
Abstract

Studies of retinal signs, as non-invasively obtained markers of microvasculature, may help to assess the microvascular contribution to ischemic cardiovascular diseases, particularly those affecting the brain. Changes in the retinal arterioles are particularly pertinent to ischemia, and several studies show their associations with MRI-assessed cerebral lacunar infarcts and white matter changes. Data are too sparse to judge the contribution to cerebral atrophy or cognitive impairment. Confounding and imprecise measurements may cloud the results of this research. A paired comparison method is proposed for avoiding some of these issues.

DOI10.1080/09286580701396712
Alternate JournalOphthalmic Epidemiol
PubMed ID17896303