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Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

TitleCross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2008
AuthorsYeh H-C, Punjabi NM, Wang N-Y, Pankow JS, Duncan BB, Cox CE, Selvin E, Brancati FL
JournalDiabetes Care
Volume31
Issue4
Pagination741-6
Date Published2008 Apr
ISSN1935-5548
KeywordsAtherosclerosis, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Prospective Studies, Respiratory Function Tests, Risk Factors, Vital Capacity
Abstract

OBJECTIVE: The aim of this study was to test the hypothesis that diabetes is independently associated with reduced lung function, both cross-sectionally and longitudinally.

RESEARCH DESIGN AND METHODS: We conducted cross-sectional and prospective analyses of diabetes status and lung function decline using baseline and 3-year follow-up data on 1,100 diabetic and 10,162 nondiabetic middle-aged adults from the Atherosclerosis Risk in Communities (ARIC) Study. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) were measured at baseline and at the 3-year follow-up using standard spirometry.

RESULTS: At baseline, adults with diabetes had significantly lower predicted FVC (96 vs. 103%, P

CONCLUSIONS: These data support the notion that the lung is a target organ for diabetic injury. Additional research is required to identify pathophysiologic mechanisms and to determine clinical significance.

DOI10.2337/dc07-1464
Alternate JournalDiabetes Care
PubMed ID18056886
PubMed Central IDPMC2773203
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
R01 HL075078 / HL / NHLBI NIH HHS / United States
M01 RR002719 / RR / NCRR NIH HHS / United States
M01-RR02719 / RR / NCRR NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
HL04065 / HL / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
5R01-DK56918 / DK / NIDDK NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
K01 DK076595-01 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
K24 DK62222 / DK / NIDDK NIH HHS / United States
HL75078 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R01 DK056918 / DK / NIDDK NIH HHS / United States
K24 DK062222 / DK / NIDDK NIH HHS / United States