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Low birthweight is associated with narrower arterioles in adults.

TitleLow birthweight is associated with narrower arterioles in adults.
Publication TypeJournal Article
Year of Publication2008
AuthorsLiew G, Wang J J, Duncan BB, Klein R, A Sharrett R, Brancati F, Yeh H-C, Mitchell P, Wong TY
Corporate AuthorsAtherosclerosis Risk in Communities Study
JournalHypertension
Volume51
Issue4
Pagination933-8
Date Published2008 Apr
ISSN1524-4563
KeywordsAged, Arterioles, Blood Pressure, Diabetic Retinopathy, Female, Humans, Hypertension, Infant, Low Birth Weight, Infant, Newborn, Male, Middle Aged, Retinal Diseases, Retinal Vessels, Risk Factors
Abstract

Low birthweight is associated with increased risk of hypertension, but underlying mechanisms are obscure. We hypothesized structural microvascular alterations may be one such mechanism. We examined the association of birthweight and retinal arteriolar caliber in 3800 persons aged 51 to 72 years participating in a population-based study in 4 US communities (the Atherosclerosis Risk in Communities study). Participants reported full-term birth and their birthweight and had retinal photography. Retinal arteriolar and venular calibers were measured from digitized retinal photographs using a validated computer-assisted method. Lower birthweight was associated with narrower retinal arteriolar caliber, with each kg lower birthweight associated with 2.4 mum (95% confidence intervals, 1.3 to 3.5, P

DOI10.1161/HYPERTENSIONAHA.107.101584
Alternate JournalHypertension
PubMed ID18268137
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
R21-HL077166 / HL / NHLBI NIH HHS / United States