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Carbohydrate intake modifies associations between ANGPTL4[E40K] genotype and HDL-cholesterol concentrations in White men from the Atherosclerosis Risk in Communities (ARIC) study.

TitleCarbohydrate intake modifies associations between ANGPTL4[E40K] genotype and HDL-cholesterol concentrations in White men from the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2009
AuthorsNettleton JA, Volcik KA, Hoogeveen RC, Boerwinkle E
JournalAtherosclerosis
Volume203
Issue1
Pagination214-20
Date Published2009 Mar
ISSN1879-1484
KeywordsAlleles, Angiopoietin-like 4 Protein, Angiopoietins, Atherosclerosis, Cholesterol, Cholesterol, HDL, Community Health Services, Diet, European Continental Ancestry Group, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Nutritional Sciences, Risk, Sex Factors, Triglycerides
Abstract

BACKGROUND: Common allelic variation in the angiopoietin-like 4 gene (ANGPTL4[E40K]) has been associated with low triglyceride (TG) and high HDL-C.

OBJECTIVE: We examined whether dietary macronutrient intake modified associations between ANGPTL4[E40K] variation and TG and HDL-C in White men and women from the Atherosclerosis Risk in Communities study.

DESIGN: Diet was assessed by food frequency questionnaire. Intake of fat (total fat [TF], saturated fat [SF], monounsaturated fat [MUFA], polyunsaturated fat [PUFA], and n-3 PUFA) and carbohydrate were expressed as percentage of total energy intake. ANGPTL4 A allele carriers (n=148 in men, 200 in women) were compared to non-carriers (n=3667 in men, 4496 in women). Interactions were tested separately in men and women, adjusting for study center, age, smoking, physical activity, BMI, and alcohol intake.

RESULTS: ANGPTL4 A allele carriers had significantly greater HDL-C and lower TG than non-carriers (p

CONCLUSIONS: These data suggest that ANGPTL4 variation and relative contributions of dietary fat and carbohydrate influence TG and HDL-C concentrations. In men, ANGPTL4 variation and dietary carbohydrate may interactively influence HDL-C.

DOI10.1016/j.atherosclerosis.2008.05.037
Alternate JournalAtherosclerosis
PubMed ID18599063
PubMed Central IDPMC2649986
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
K01 DK082729-01 / DK / NIDDK NIH HHS / United States