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HDL-cholesterol and incidence of breast cancer in the ARIC cohort study.

TitleHDL-cholesterol and incidence of breast cancer in the ARIC cohort study.
Publication TypeJournal Article
Year of Publication2008
AuthorsKucharska-Newton AM, Rosamond WD, Mink PJ, Alberg AJ, Shahar E, Folsom AR
JournalAnn Epidemiol
Volume18
Issue9
Pagination671-7
Date Published2008 Sep
ISSN1873-2585
KeywordsBiomarkers, Breast Neoplasms, Cholesterol, HDL, Female, Humans, Incidence, Middle Aged, Premenopause, Prospective Studies, Risk Assessment, Risk Factors, Sensitivity and Specificity
Abstract

PURPOSE: An association of low plasma HDL-cholesterol with risk of breast cancer has been suggested by multiple studies; the evidence, however, is not conclusive. We examined the possible association of low HDL-cholesterol with incidence of breast cancer using data from the Atherosclerosis Risk in Communities Study (ARIC) cohort, a prospective study of a randomly selected sample of women and men from four U.S. communities.

METHODS: Among 7,575 female members of the ARIC cohort, 359 cases of incident breast cancer were ascertained during the follow-up from 1987 through 2000.

RESULTS: In analysis adjusted for age, race, body mass index, smoking, and reproductive variables, we observed no association of low baseline HDL-cholesterol (

CONCLUSION: Results of our study suggest that low HDL-cholesterol among premenopausal women may be a marker of increased breast cancer risk.

DOI10.1016/j.annepidem.2008.06.006
Alternate JournalAnn Epidemiol
PubMed ID18794007
PubMed Central IDPMC2566531
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States