Title | HDL-cholesterol and incidence of breast cancer in the ARIC cohort study. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Kucharska-Newton AM, Rosamond WD, Mink PJ, Alberg AJ, Shahar E, Folsom AR |
Journal | Ann Epidemiol |
Volume | 18 |
Issue | 9 |
Pagination | 671-7 |
Date Published | 2008 Sep |
ISSN | 1873-2585 |
Keywords | Biomarkers, Breast Neoplasms, Cholesterol, HDL, Female, Humans, Incidence, Middle Aged, Premenopause, Prospective Studies, Risk Assessment, Risk Factors, Sensitivity and Specificity |
Abstract | PURPOSE: An association of low plasma HDL-cholesterol with risk of breast cancer has been suggested by multiple studies; the evidence, however, is not conclusive. We examined the possible association of low HDL-cholesterol with incidence of breast cancer using data from the Atherosclerosis Risk in Communities Study (ARIC) cohort, a prospective study of a randomly selected sample of women and men from four U.S. communities. METHODS: Among 7,575 female members of the ARIC cohort, 359 cases of incident breast cancer were ascertained during the follow-up from 1987 through 2000. RESULTS: In analysis adjusted for age, race, body mass index, smoking, and reproductive variables, we observed no association of low baseline HDL-cholesterol ( CONCLUSION: Results of our study suggest that low HDL-cholesterol among premenopausal women may be a marker of increased breast cancer risk. |
DOI | 10.1016/j.annepidem.2008.06.006 |
Alternate Journal | Ann Epidemiol |
PubMed ID | 18794007 |
PubMed Central ID | PMC2566531 |
Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01 HC055018 / HC / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States |