|Title||Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Nettleton JA, Volcik KA, Demerath EW, Boerwinkle E, Folsom AR|
|Date Published||2008 Nov|
|Keywords||Aged, Angiopoietin-Like Protein 4, Angiopoietins, Atherosclerosis, Body Mass Index, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Triglycerides, United States, Weight Gain|
PURPOSE: Allelic variation in the adipokine angiopoietin-like 4 gene (ANGPTL4[E40K]) has been cross-sectionally associated with triglycerides, but the effects of genotype, or the interaction between genotype and body weight, on longitudinal triglyceride change have not been studied.
METHODS: Body weight, triglycerides, and ANGPTL4[E40K] genotype were determined at baseline (1987-1989) and at 3 follow-up exams (1990-1992, 1993-1995, 1996-1998) in 7,939 white ANGPTL4[E40K] G allele homozygotes and 344 A allele carriers. Changes in body weight and triglycerides were characterized as the difference between exam 4 and baseline measurements.
RESULTS: ANGPTL4[E40K] A allele carriers had triglyceride concentrations that were 15 to 18 mg/dL lower than G allele homozygotes at all exams (P
CONCLUSIONS: Differences in triglyceride concentrations between ANGPTL4[E40K] A allele carriers and G allele homozygotes are maintained over time, but the degree of increase in triglycerides was similar between groups and was not modified by body weight changes.
|Alternate Journal||Ann Epidemiol|
|PubMed Central ID||PMC2582040|
|Grant List||N01-HC-55022 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States