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Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study.

TitleChanges in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2008
AuthorsPeeters A, Magliano DJ, Stevens J, Duncan BB, Klein R, Wong TY
JournalArch Ophthalmol
Volume126
Issue11
Pagination1554-60
Date Published2008 Nov
ISSN1538-3601
KeywordsAbdominal Fat, Atherosclerosis, Body Mass Index, Body Weight, Female, Follow-Up Studies, Humans, Macular Degeneration, Male, Middle Aged, Obesity, Odds Ratio, Risk Factors, United States, Waist-Hip Ratio
Abstract

OBJECTIVE: To examine the association between changes in waist-hip ratio (WHR), a measure of abdominal obesity, and age-related macular degeneration (AMD).

METHODS: A total of 12 515 persons from a population-based cohort study, aged 45 to 64 years in 1987 to 1989, were followed up over 6 years. The percentage change in WHR during follow-up was ranked into sex-specific deciles; an increase in WHR was defined as the top 10% of change and a decrease in WHR as the bottom 10%. The association of increased or decreased WHR and presence of AMD at follow-up was determined using logistic regression adjusting for potential confounders.

RESULTS: The average change in WHR was an increase of 2%, ranging from a decrease of 44% to an increase of 102%. A decrease in WHR of 3% or more was associated with 29% lower odds of any AMD (odds ratio = 0.71; 95% confidence interval, 0.52-0.97). This effect was most pronounced among obese participants at baseline, where a decrease in WHR was associated with 59% lower odds of AMD (odds ratio = 0.41; 95% confidence interval, 0.20-0.82).

CONCLUSIONS: Middle-aged persons who had a 3% or greater reduction in WHR over time were less likely to have AMD, particularly among those who were initially obese.

DOI10.1001/archopht.126.11.1554
Alternate JournalArch Ophthalmol
PubMed ID19001224
PubMed Central IDPMC5774859
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States