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Plasma fatty acid composition and incident heart failure in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.

TitlePlasma fatty acid composition and incident heart failure in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2008
AuthorsYamagishi K, Nettleton JA, Folsom AR
Corporate AuthorsARIC Study Investigators
JournalAm Heart J
Volume156
Issue5
Pagination965-74
Date Published2008 Nov
ISSN1097-6744
KeywordsFatty Acids, Female, Follow-Up Studies, Heart Failure, Humans, Male, Middle Aged
Abstract

BACKGROUND: Some previous prospective studies showed that dietary intake of omega3 polyunsaturated fatty acids was associated with lower risk of heart failure (HF), but no study has examined the association between plasma fatty acids and HF.

METHODS: We included 3,592 white participants from the Minneapolis field center of the Atherosclerosis Risk in Communities (ARIC) Study, aged 45 to 64 at baseline (1987-1989), initially free of coronary heart disease, stroke, and HF and who had cholesterol ester and phospholipid plasma fatty acids measured. Participants were followed through 2003, and incident HF was defined by a hospital discharge or death including a HF International Classification of Diseases code.

RESULTS: During the 14.3-year follow-up, we identified 197 cases of HF (110 for men and 87 for women). After adjustment for age and other confounders, higher saturated fatty acids, especially myristic (14:0) acid, were associated positively with incident HF in both men and women. Higher arachidonic (20:3,omega6) and long-chain omega3 polyunsaturated fatty acids, especially docosahexaenoic (22:6,omega3) acid, were associated inversely with HF in women but not in men. Neither plasma alpha-linolenic nor eicosapentaenoic acid was associated with incident HF.

CONCLUSIONS: In both men and women, greater levels of saturated fatty acids may increase risk of HF. In women, arachidonic acid and long-chain omega3 polyunsaturated fatty acids may decrease risk of HF.

DOI10.1016/j.ahj.2008.06.017
Alternate JournalAm Heart J
PubMed ID19061714
PubMed Central IDPMC2671634
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States