Title | Risk factor correlates of platelet and leukocyte markers assessed by flow cytometry in a population-based sample. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Folsom AR, Aleksic N, Sanhueza A, Boerwinkle E |
Journal | Atherosclerosis |
Volume | 205 |
Issue | 1 |
Pagination | 272-8 |
Date Published | 2009 Jul |
ISSN | 1879-1484 |
Keywords | Blood Platelets, Cholesterol, LDL, Female, Flow Cytometry, Granulocytes, Humans, Leukocytes, Lymphocytes, Male, Membrane Glycoproteins, Peroxidase, Risk, Risk Factors, Thrombosis, Toll-Like Receptor 4 |
Abstract | BACKGROUND: Platelet and leukocyte products are involved in atherothrombosis. However, the determinants of platelet and leukocyte markers assessed by flow cytometry have not been documented in a population-based sample. METHODS AND RESULTS: We performed flow cytometry on blood from participants (n=1894) in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. Cellular aggregates and multiple platelet and leukocyte markers, such as myeloperoxidase in granulocytes and toll-like receptor-4, CD14, and CD45 in monocytes, were quantified. Their cross-sectional associations with demographic and risk factors were assessed using multiple linear regression. Mean values of most cellular markers and aggregates were considerably higher in blacks than whites (p CONCLUSIONS: Race/ethnicity, sex, and to a lesser degree LDL-cholesterol and cholesterol-lowering therapy, but few other risk factors, were correlated with markers of cellular activation in this population-based study. |
DOI | 10.1016/j.atherosclerosis.2008.11.005 |
Alternate Journal | Atherosclerosis |
PubMed ID | 19124123 |
PubMed Central ID | PMC2700209 |
Grant List | N01-HC-55016 / HC / NHLBI NIH HHS / United States U01 HL075572 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01 HC055019 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC- 55019 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States U01-HL075572 / HL / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01-HC- 55020 / HC / NHLBI NIH HHS / United States |