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Risk factor correlates of platelet and leukocyte markers assessed by flow cytometry in a population-based sample.

TitleRisk factor correlates of platelet and leukocyte markers assessed by flow cytometry in a population-based sample.
Publication TypeJournal Article
Year of Publication2009
AuthorsFolsom AR, Aleksic N, Sanhueza A, Boerwinkle E
JournalAtherosclerosis
Volume205
Issue1
Pagination272-8
Date Published2009 Jul
ISSN1879-1484
KeywordsBlood Platelets, Cholesterol, LDL, Female, Flow Cytometry, Granulocytes, Humans, Leukocytes, Lymphocytes, Male, Membrane Glycoproteins, Peroxidase, Risk, Risk Factors, Thrombosis, Toll-Like Receptor 4
Abstract

BACKGROUND: Platelet and leukocyte products are involved in atherothrombosis. However, the determinants of platelet and leukocyte markers assessed by flow cytometry have not been documented in a population-based sample.

METHODS AND RESULTS: We performed flow cytometry on blood from participants (n=1894) in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. Cellular aggregates and multiple platelet and leukocyte markers, such as myeloperoxidase in granulocytes and toll-like receptor-4, CD14, and CD45 in monocytes, were quantified. Their cross-sectional associations with demographic and risk factors were assessed using multiple linear regression. Mean values of most cellular markers and aggregates were considerably higher in blacks than whites (p

CONCLUSIONS: Race/ethnicity, sex, and to a lesser degree LDL-cholesterol and cholesterol-lowering therapy, but few other risk factors, were correlated with markers of cellular activation in this population-based study.

DOI10.1016/j.atherosclerosis.2008.11.005
Alternate JournalAtherosclerosis
PubMed ID19124123
PubMed Central IDPMC2700209
Grant ListN01-HC-55022 / HC / NHLBI NIH HHS / United States
U01-HL075572 / HL / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
U01 HL075572 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC- 55020 / HC / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC- 55019 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States