Title | Common variants at ten loci modulate the QT interval duration in the QTSCD Study. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Pfeufer A, Sanna S, Arking DE, Müller M, Gateva V, Fuchsberger C, Ehret GB, Orrú M, Pattaro C, Köttgen A, Perz S, Usala G, Barbalic M, Li M, Pütz B, Scuteri A, Prineas RJ, Sinner MF, Gieger C, Najjar SS, Kao LWH, Mühleisen TW, Dei M, Happle C, Möhlenkamp S, Crisponi L, Erbel R, Jöckel K-H, Naitza S, Steinbeck G, Marroni F, Hicks AA, Lakatta E, Müller-Myhsok B, Pramstaller PP, Wichmann H-E, Schlessinger D, Boerwinkle E, Meitinger T, Uda M, Coresh J, Kääb S, Abecasis GR, Chakravarti A |
Journal | Nat Genet |
Volume | 41 |
Issue | 4 |
Pagination | 407-14 |
Date Published | 2009 Apr |
ISSN | 1546-1718 |
Keywords | Arrhythmias, Cardiac, Chromosome Mapping, Electrocardiography, Electrophysiology, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, Genetic Variation, Heart, Humans, Ion Channels, KCNQ1 Potassium Channel, Long QT Syndrome, Muscle Proteins, NAV1.5 Voltage-Gated Sodium Channel, Potassium Channels, Inwardly Rectifying, Reproducibility of Results, Sodium Channels |
Abstract | The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death (SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We analyze genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P |
DOI | 10.1038/ng.362 |
Alternate Journal | Nat Genet |
PubMed ID | 19305409 |
PubMed Central ID | PMC2976045 |
Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States 263-MA-410953 / / PHS HHS / United States / ImNIH / Intramural NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States U10 HL054512 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-AG-12109 / AG / NIA NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States R01 HL59367 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States HL054512 / HL / NHLBI NIH HHS / United States HL86694 / HL / NHLBI NIH HHS / United States U01 HL054512-13 / HL / NHLBI NIH HHS / United States R01 HL086694-03 / HL / NHLBI NIH HHS / United States HHSN 268200625226C / / PHS HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States U01 HL054512 / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States |