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Physical activity and subclinical MRI cerebral infarcts: the ARIC Study.

TitlePhysical activity and subclinical MRI cerebral infarcts: the ARIC Study.
Publication TypeJournal Article
Year of Publication2009
AuthorsDubbert PM, Penman AD, Evenson KR, Reeves RR, Mosley TH
JournalJ Neurol Sci
Volume284
Issue1-2
Pagination135-9
Date Published2009 Sep 15
ISSN1878-5883
KeywordsAfrican Americans, Atherosclerosis, Cerebral Infarction, Cross-Sectional Studies, Disease Susceptibility, Female, Follow-Up Studies, Habits, Humans, Leisure Activities, Magnetic Resonance Imaging, Male, Middle Aged, Motor Activity, Occupations, Posture, Prospective Studies, Risk, Risk Factors, Sports, United States
Abstract

BACKGROUND: We hypothesized that physical activity (PA), which is often associated with reduced risk of ischemic stroke, may also be associated with reduced risk of subclinical cerebral infarcts.

OBJECTIVES: We studied the cross-sectional association between PA and subclinical cerebral infarcts among African-Americans in the Atherosclerosis Risk in Communities (ARIC) Study.

METHODS: PA self-reported at baseline and images from cerebral MRI examination obtained 6 years later were evaluated for presence and location of subclinical infarcts > or = 3 mm in size. After exclusions, 944 participants were eligible for study.

RESULTS: The results suggested an inverse relationship between odds of having a subclinical cerebral infarct and level of PA on several measures, although the multivariable adjusted odds ratios (OR) were statistically significant only for the sport score. A 1-unit increase in the sport score, indicating more leisure PA, was associated with an adjusted OR for having a subclinical cerebral infarct of 0.62 (0.44-0.87), with a statistically significant monotonic trend across quartiles of the score (P = 0.01). There was no association of work scores with subclinical infarcts.

CONCLUSIONS: In African-Americans, sport PA was inversely related to subclinical MRI-detected cerebral infarcts assessed six years later.

DOI10.1016/j.jns.2009.04.011
Alternate JournalJ Neurol Sci
PubMed ID19447410
PubMed Central IDPMC2728475
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01 HC055022 / HC / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States