Title | Physical activity and subclinical MRI cerebral infarcts: the ARIC Study. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Dubbert PM, Penman AD, Evenson KR, Reeves RR, Mosley TH |
Journal | J Neurol Sci |
Volume | 284 |
Issue | 1-2 |
Pagination | 135-9 |
Date Published | 2009 Sep 15 |
ISSN | 1878-5883 |
Keywords | Atherosclerosis, Black or African American, Cerebral Infarction, Cross-Sectional Studies, Disease Susceptibility, Female, Follow-Up Studies, Habits, Humans, Leisure Activities, Magnetic Resonance Imaging, Male, Middle Aged, Motor Activity, Occupations, Posture, Prospective Studies, Risk, Risk Factors, Sports, United States |
Abstract | BACKGROUND: We hypothesized that physical activity (PA), which is often associated with reduced risk of ischemic stroke, may also be associated with reduced risk of subclinical cerebral infarcts. OBJECTIVES: We studied the cross-sectional association between PA and subclinical cerebral infarcts among African-Americans in the Atherosclerosis Risk in Communities (ARIC) Study. METHODS: PA self-reported at baseline and images from cerebral MRI examination obtained 6 years later were evaluated for presence and location of subclinical infarcts > or = 3 mm in size. After exclusions, 944 participants were eligible for study. RESULTS: The results suggested an inverse relationship between odds of having a subclinical cerebral infarct and level of PA on several measures, although the multivariable adjusted odds ratios (OR) were statistically significant only for the sport score. A 1-unit increase in the sport score, indicating more leisure PA, was associated with an adjusted OR for having a subclinical cerebral infarct of 0.62 (0.44-0.87), with a statistically significant monotonic trend across quartiles of the score (P = 0.01). There was no association of work scores with subclinical infarcts. CONCLUSIONS: In African-Americans, sport PA was inversely related to subclinical MRI-detected cerebral infarcts assessed six years later. |
DOI | 10.1016/j.jns.2009.04.011 |
Alternate Journal | J Neurol Sci |
PubMed ID | 19447410 |
PubMed Central ID | PMC2728475 |
Grant List | N01HC55018 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States N01HC55020 / HL / NHLBI NIH HHS / United States N01 HC055022 / HC / NHLBI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States |