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Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

TitleMeta-analysis of genome-wide association data identifies two loci influencing age at menarche.
Publication TypeJournal Article
Year of Publication2009
AuthorsPerry JRB, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM
JournalNat Genet
Volume41
Issue6
Pagination648-50
Date Published2009 Jun
ISSN1546-1718
KeywordsAdolescent, Age Factors, Body Mass Index, Child, Chromosome Mapping, Chromosomes, Human, Pair 6, Chromosomes, Human, Pair 8, Chromosomes, Human, Pair 9, DNA-Binding Proteins, Female, Genetic Variation, Genome-Wide Association Study, Humans, Menarche, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, RNA-Binding Proteins, Sexual Maturation
Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
DOI10.1038/ng.386
Alternate JournalNat Genet
PubMed ID19448620
PubMed Central IDPMC2942986
Grant ListN.1-AG-1-2111 / AG / NIA NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N02 HL64278 / HL / NHLBI NIH HHS / United States
R01 AR041398 / AR / NIAMS NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
P30 DK072488 / DK / NIDDK NIH HHS / United States
U01 HL072515-06 / HL / NHLBI NIH HHS / United States
N01 HC055021 / HC / NHLBI NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
R21AG032598 / AG / NIA NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-AG-5-0002 / AG / NIA NIH HHS / United States
N01 HC055016 / HC / NHLBI NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
N01 HC055022 / HC / NHLBI NIH HHS / United States
/ WT_ / Wellcome Trust / United Kingdom
N01 AG012100 / AG / NIA NIH HHS / United States
U01 HL72515 / HL / NHLBI NIH HHS / United States
U19 AG023122 / AG / NIA NIH HHS / United States
263 MD 821336 / MD / NIMHD NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
R01 AR/AG 41398 / AG / NIA NIH HHS / United States
R01 AR041398-15 / AR / NIAMS NIH HHS / United States
M01 RR 16500 / RR / NCRR NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
M01 RR016500-02 / RR / NCRR NIH HHS / United States
263 MD821336 / MD / NIMHD NIH HHS / United States
263 MD9164 13 / MD / NIMHD NIH HHS / United States
U19 AG023122-05 / AG / NIA NIH HHS / United States
R21 AG032598-02 / AG / NIA NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N.1-AG-1-1 / AG / NIA NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
U01 HL072515 / HL / NHLBI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
/ ImNIH / Intramural NIH HHS / United States
N01-AG-12100 / AG / NIA NIH HHS / United States
R21 AG032598 / AG / NIA NIH HHS / United States
P30 DK072488-02 / DK / NIDDK NIH HHS / United States
263 MD 9164 / MD / NIMHD NIH HHS / United States