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Association of systemic oxidative stress with suppressed serum IgG to commensal oral biofilm and modulation by periodontal infection.

TitleAssociation of systemic oxidative stress with suppressed serum IgG to commensal oral biofilm and modulation by periodontal infection.
Publication TypeJournal Article
Year of Publication2009
AuthorsSinger RE, Moss K, Beck JD, Offenbacher S
JournalAntioxid Redox Signal
Volume11
Issue12
Pagination2973-83
Date Published2009 Dec
ISSN1557-7716
KeywordsAdult, Biofilms, Cohort Studies, Dinoprost, Humans, Immunoglobulin G, Middle Aged, Mouth, Oxidative Stress, Periodontal Diseases
Abstract

To assess the impact of systemic oxidative stress on humoral immune responses, we examined the relation between levels of serum 8-isoprostane and serum IgG antibodies against 17 microorganisms in the commensal oral biofilm among the ARIC population of community-dwelling adults (n = 4,717). Bivariately, serum 8-isoprostane was associated with age, race/center, education, smoking, serum triglycerides, and the extent of periodontal disease severity. Total IgG antibody directed to the oral biofilm was significantly associated with race/center, hypertension, triglycerides, periodontal disease severity, plaque, and serum 8-isoprostane. In multivariate models, the highest quartile of increased 8-isoprostane displayed marked reductions (44%) in biofilm IgG antibody in contrast to small increases in total IgG antibody level for the highest quartiles of oral bacterial burden or periodontal disease severity (19 and 12%, respectively; p

DOI10.1089/ARS.2009.2591
Alternate JournalAntioxid Redox Signal
PubMed ID19496702
PubMed Central IDPMC2861534
Grant ListN01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
DE-O7310 / DE / NIDCR NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
UL1RR025747 / RR / NCRR NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
RR00046 / RR / NCRR NIH HHS / United States