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Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study.

TitlePolysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study.
Publication TypeJournal Article
Year of Publication2009
AuthorsWinkelman JW, Redline S, Baldwin CM, Resnick HE, Newman AB, Gottlieb DJ
JournalSleep
Volume32
Issue6
Pagination772-8
Date Published2009 Jun
ISSN0161-8105
KeywordsAdult, Aged, Cohort Studies, Comorbidity, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Polysomnography, Prospective Studies, Quality of Life, Restless Legs Syndrome, Sleep Initiation and Maintenance Disorders, Statistics as Topic
Abstract

STUDY OBJECTIVES: Sleep disturbance is the primary clinical morbidity of restless legs syndrome (RLS). To date, sleep disturbance in RLS has been measured in (1) clinical samples with polysomnography (PSG) or (2) population-based samples by self-report. The objective of this study was to analyze sleep by PSG in a population-based sample with symptoms of RLS.

DESIGN: Cross-sectional observational study.

SETTING: Community-based.

PARTICIPANTS: 3433 older men and women.

INTERVENTIONS: None.

MEASUREMENTS AND RESULTS: RLS was evaluated using an 8-item self-administered questionnaire based on NIH diagnostic criteria and required symptoms occurring > or = five times per month and associated with at least moderate distress. Health-related quality of life (HRQOL) was determined using the SF-36. Unattended, in-home PSG was performed. Data were assessed using general linear models with adjustment for demographic, health-related variables, and apnea-hypopnea index (AHI). Subjects with RLS had longer adjusted mean sleep latency (39.8 vs 26.4 min, P

CONCLUSIONS: These novel PSG data from a nonclinical, community-based sample of individuals with RLS document sleep disturbance in the home even in individuals with intermittent symptoms.

DOI10.1093/sleep/32.6.772
Alternate JournalSleep
PubMed ID19544754
PubMed Central IDPMC2690565
Grant ListU01 HL053916 / HL / NHLBI NIH HHS / United States
U01 HL063463 / HL / NHLBI NIH HHS / United States
R01 HL71515 / HL / NHLBI NIH HHS / United States
U01 HL53938 / HL / NHLBI NIH HHS / United States
U01 HL53916 / HL / NHLBI NIH HHS / United States
U01 HL053938 / HL / NHLBI NIH HHS / United States
U01 HL064360 / HL / NHLBI NIH HHS / United States
U01 HL53937 / HL / NHLBI NIH HHS / United States
U01 HL053941 / HL / NHLBI NIH HHS / United States
HL53938-07S1 / HL / NHLBI NIH HHS / United States
R01 HL071515 / HL / NHLBI NIH HHS / United States
U01 HL53940 / HL / NHLBI NIH HHS / United States
U01 HL63463 / HL / NHLBI NIH HHS / United States
U01 HL053934 / HL / NHLBI NIH HHS / United States
U01 HL063429 / HL / NHLBI NIH HHS / United States
U01 HL53931 / HL / NHLBI NIH HHS / United States
U01 HL053937 / HL / NHLBI NIH HHS / United States
U01 HL53934 / HL / NHLBI NIH HHS / United States
U01 HL63429 / HL / NHLBI NIH HHS / United States
U01 HL53941 / HL / NHLBI NIH HHS / United States
U01 HL64360 / HL / NHLBI NIH HHS / United States
U01 HL053931 / HL / NHLBI NIH HHS / United States