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The relationship between self-reported history of endodontic therapy and coronary heart disease in the Atherosclerosis Risk in Communities Study.

TitleThe relationship between self-reported history of endodontic therapy and coronary heart disease in the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2009
AuthorsCaplan DJ, Pankow JS, Cai J, Offenbacher S, Beck JD
JournalJ Am Dent Assoc
Volume140
Issue8
Pagination1004-12
Date Published2009 Aug
ISSN1943-4723
KeywordsAge Factors, Atherosclerosis, Cohort Studies, Continental Population Groups, Coronary Disease, Cross-Sectional Studies, Crowns, Dental Caries, Dental Pulp Diseases, Diabetes Mellitus, DMF Index, Epidemiologic Studies, Female, Humans, Hypertension, Jaw, Edentulous, Partially, Longitudinal Studies, Male, Middle Aged, Periodontal Attachment Loss, Periodontal Pocket, Physical Examination, Prevalence, Prospective Studies, Root Canal Therapy, Sex Factors, Smoking, Surveys and Questionnaires, United States
Abstract

BACKGROUND: Results from numerous studies have suggested links between periodontal disease and coronary heart disease (CHD), but endodontic disease has not been studied extensively in this regard.

METHODS: The authors evaluated the relationship between self-reported history of endodontic therapy (ET) and prevalent CHD in the Atherosclerosis Risk in Communities (ARIC) Study, aprospective epidemiologic study sponsored by the National Heart, Lung, and Blood Institute. The authors used multivariable logistic regressionto analyze data obtained from oral health questionnaires, medical evaluations and clinical dental examinations.

RESULTS: Of 6,651 participants analyzed, 50.4 percent reported never having had ET; 21.5 percent reported having had ET one time; and 28.0 percent reported having had ET two or more times. Final multivariable regression models indicated that among participants with 25 or more teeth, those reporting having had ET two or more times had 1.62 (95 percent confidence interval [CI], 1.04-2.53) times the odds of prevalent CHD compared with those reporting never having had ET. Among participants with 24 or fewer teeth, no significant differences in CHD prevalence were observed among groups regardless of their history of ET.

CONCLUSIONS: Among participants with 25 or more teeth, those with a greater self-reported history of ET were more likely to have CHD than were those reporting no history of ET.

CLINICAL IMPLICATIONS: More accurate epidemiologic quantification of endodontic infection and inflammation is required before definitive conclusions can be made about potential relationships between endodontic disease and CHD.

DOI10.14219/jada.archive.2009.0311
Alternate JournalJ Am Dent Assoc
PubMed ID19654253
PubMed Central IDPMC2735042
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01 HC055022 / HC / NHLBI NIH HHS / United States
R01 DE011551 / DE / NIDCR NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
R01 DE011551-04 / DE / NIDCR NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
N01 HC055021 / HC / NHLBI NIH HHS / United States
DE13807-01A1 / DE / NIDCR NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
DE11551 / DE / NIDCR NIH HHS / United States
R01 DE013807-01A1 / DE / NIDCR NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
N01 HC055016 / HC / NHLBI NIH HHS / United States