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Associations of chronic obstructive pulmonary disease with all-cause mortality in Blacks and Whites: the atherosclerosis risk in communities (ARIC) study.

TitleAssociations of chronic obstructive pulmonary disease with all-cause mortality in Blacks and Whites: the atherosclerosis risk in communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2009
AuthorsChamberlain AM, Schabath MB, Folsom AR
JournalEthn Dis
Volume19
Issue3
Pagination308-14
Date Published2009 Summer
ISSN1049-510X
KeywordsAfrican Americans, European Continental Ancestry Group, Female, Humans, Male, Maryland, Middle Aged, Minnesota, Mississippi, North Carolina, Proportional Hazards Models, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Severity of Illness Index
Abstract

OBJECTIVE: To determine the burden of chronic obstructive pulmonary disease (COPD) on all-cause mortality in Blacks and Whites from four US communities.

METHODS: We determined prospectively the risk of death through December 2004 in relation to baseline (1987-1989) COPD status in 10,333 Black and White participants of the Atherosclerosis Risk in Communities (ARIC) study.

RESULTS: Over a mean follow-up of 15 years (maximum 18 years), 462 deaths occurred in Blacks and 1221 deaths occurred in Whites. Hazard ratios for all-cause mortality among Blacks and Whites were similar (hazard ratio [HR] = 1.74 in Blacks and HR = 1.59 in Whites), indicating a 59%-74% greater risk of mortality for those with COPD. However, for both those with and without COPD, crude death rates were approximately double in Blacks compared to Whites.

CONCLUSIONS: Our findings suggest that given COPD, Blacks and Whites have the same proportionate increase in mortality and that the difference in death rates between Blacks and Whites cannot be explained by COPD status. The public health burden of COPD is enormous, and strategies to reduce COPD and smoking could have a large impact on total mortality rates of both Blacks and Whites.

Alternate JournalEthn Dis
PubMed ID19769014
PubMed Central IDPMC2826210
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
T32-HL-007779 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States