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C-reactive protein and venous thromboembolism. A prospective investigation in the ARIC cohort.

TitleC-reactive protein and venous thromboembolism. A prospective investigation in the ARIC cohort.
Publication TypeJournal Article
Year of Publication2009
AuthorsFolsom AR, Lutsey PL, Astor BC
Secondary AuthorsCushman M
JournalThromb Haemost
Volume102
Issue4
Pagination615-9
Date Published2009 Oct
ISSN0340-6245
KeywordsAtherosclerosis, Biomarkers, C-Reactive Protein, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Population Groups, Prognosis, Prospective Studies, Risk Factors, United States, Venous Thromboembolism
Abstract

The role of inflammation in the causation of venous thromboembolism (VTE) is uncertain. In 10,505 participants of the Atherosclerosis Risk in Communities (ARIC) Study, we assessed the association of the systemic inflammation marker, elevated C-reactive protein (CRP), with incidence of VTE (n=221) over a median of 8.3 years of follow-up. Adjusted for age, race, and sex, the hazard ratios of VTE across quintiles of CRP were 1.0, 1.61, 1.16, 1.56, and 2.31 (p for trend p or = 8.55 mg/L), compared with the lowest 90% of CRP values, the hazard ratio of VTE was 2.07 (95% CI 1.47, 2.94). Further adjustment for baseline hormone replacement therapy, diabetes, and body mass index attenuated the hazard ratios only slightly. For example, the adjusted hazard ratio of VTE was 1.76 (95% CI 1.23, 2.52) for CRP above versus below the 90(th) percentile. In conclusion, this prospective, population-based study suggests elevated CRP is independently associated with increased risk of VTE.

DOI10.1160/TH09-04-0274
Alternate JournalThromb Haemost
PubMed ID19806245
PubMed Central IDPMC2810122
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
R01 HL59367 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R01 DK076770 / DK / NIDDK NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
R01 HL059367-09 / HL / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States