| Title | Uromodulin levels associate with a common UMOD variant and risk for incident CKD. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Köttgen A, Hwang S-J, Larson MG, Van Eyk JE, Fu Q, Benjamin EJ, Dehghan A, Glazer NL, Kao LWH, Harris TB, Gudnason V, Shlipak MG, Yang Q, Coresh J, Levy D, Fox CS |
| Journal | J Am Soc Nephrol |
| Volume | 21 |
| Issue | 2 |
| Pagination | 337-44 |
| Date Published | 2010 Feb |
| ISSN | 1533-3450 |
| Keywords | Aged, Aged, 80 and over, Case-Control Studies, Chronic Disease, Female, Genetic Predisposition to Disease, Genotype, Glomerular Filtration Rate, Humans, Kidney Diseases, Kidney Diseases, Cystic, Male, Middle Aged, Molecular Motor Proteins, Mucoproteins, Myosin Heavy Chains, Polymorphism, Single Nucleotide, Risk Factors, Uromodulin |
| Abstract | Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associate with UMOD variants or with the risk for developing CKD is unknown. We conducted an age- and gender-matched case-control study (n = 200) of incident CKD (eGFR |
| DOI | 10.1681/ASN.2009070725 |
| Alternate Journal | J Am Soc Nephrol |
| PubMed ID | 19959715 |
| PubMed Central ID | PMC2834540 |
| Grant List | UL1 RR025005 / RR / NCRR NIH HHS / United States R01 HL092577 / HL / NHLBI NIH HHS / United States U01 DK085689-01 / DK / NIDDK NIH HHS / United States N01-HV-28180 / HV / NHLBI NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States R01 DK076770 / DK / NIDDK NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States R01-DK076770-01 / DK / NIDDK NIH HHS / United States 5UL1 RR025005-3 / RR / NCRR NIH HHS / United States N01HC55020 / HL / NHLBI NIH HHS / United States N01-HC-25195 / HC / NHLBI NIH HHS / United States AG028321 / AG / NIA NIH HHS / United States HL092577-01A1 / HL / NHLBI NIH HHS / United States 1U54RR023561-01A1 / RR / NCRR NIH HHS / United States U01 DK085689 / DK / NIDDK NIH HHS / United States N01HV28180 / HL / NHLBI NIH HHS / United States R01 AG028321 / AG / NIA NIH HHS / United States |