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Uromodulin levels associate with a common UMOD variant and risk for incident CKD.

TitleUromodulin levels associate with a common UMOD variant and risk for incident CKD.
Publication TypeJournal Article
Year of Publication2010
AuthorsKöttgen A, Hwang S-J, Larson MG, Van Eyk JE, Fu Q, Benjamin EJ, Dehghan A, Glazer NL, Kao LWH, Harris TB, Gudnason V, Shlipak MG, Yang Q, Coresh J, Levy D, Fox CS
JournalJ Am Soc Nephrol
Volume21
Issue2
Pagination337-44
Date Published2010 Feb
ISSN1533-3450
KeywordsAged, Aged, 80 and over, Case-Control Studies, Chronic Disease, Female, Genetic Predisposition to Disease, Genotype, Glomerular Filtration Rate, Humans, Kidney Diseases, Kidney Diseases, Cystic, Male, Middle Aged, Molecular Motor Proteins, Mucoproteins, Myosin Heavy Chains, Polymorphism, Single Nucleotide, Risk Factors, Uromodulin
Abstract

Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associate with UMOD variants or with the risk for developing CKD is unknown. We conducted an age- and gender-matched case-control study (n = 200) of incident CKD (eGFR

DOI10.1681/ASN.2009070725
Alternate JournalJ Am Soc Nephrol
PubMed ID19959715
PubMed Central IDPMC2834540
Grant List5UL1 RR025005-3 / RR / NCRR NIH HHS / United States
N01HC55020 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
R01 HL092577 / HL / NHLBI NIH HHS / United States
U01 DK085689-01 / DK / NIDDK NIH HHS / United States
N01-HV-28180 / HV / NHLBI NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
AG028321 / AG / NIA NIH HHS / United States
HL092577-01A1 / HL / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
R01 DK076770 / DK / NIDDK NIH HHS / United States
1U54RR023561-01A1 / RR / NCRR NIH HHS / United States
U01 DK085689 / DK / NIDDK NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
R01-DK076770-01 / DK / NIDDK NIH HHS / United States
N01HV28180 / HL / NHLBI NIH HHS / United States
R01 AG028321 / AG / NIA NIH HHS / United States